Association Between Genes in the Nuclear Factor E2–Related Factor 2 Antioxidative Response Elements Pathway and Cancer-Related Fatigue in Women With Early-Stage Breast Cancer

Tara S. Davis

Theresa A. Koleck

Margaret Q. Rosenzweig

Christine Miaskowski

Kirk I. Erickson

Susan M. Sereika

Catherine M. Bender

Yvette P. Conley

antioxidants, breast neoplasms, DNA methylation, fatigue, polymorphism
ONF 2024, 51(4), 404-416. DOI: 10.1188/24.ONF.404-416

Objectives: To explore genes in the nuclear factor E2–related factor 2 antioxidative response elements (Nrf2-ARE) signaling pathway using a multiomics approach for associations with variability of cancer-related fatigue (CRF) in postmenopausal women with early-stage hormone receptor–positive breast cancer.

Sample & Setting: Postmenopausal women (N = 116) with early-stage hormone receptor–positive breast cancer were recruited from western Pennsylvania.

Methods & Variables: Candidate genes from the Nrf2-ARE pathway were investigated for associations with CRF occurrence and severity. Associations were evaluated using logistic regression for occurrence and linear regression for severity.

Results: The rs2706110 TT genotype in NFE2L2 was associated with a 3.5-fold increase in odds of CRF occurrence. The cytosine-phosphate-guanine (CpG) site cg22820568 in PRDX1 was associated with CRF occurrence and severity.

Implications for Nursing: Biomarkers based on Nrf2-ARE genes may help to identify women at increased risk for more severe CRF and to develop targeted interventions.

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