An increase in sedentary lifestyle has been identified as a potential risk factor for the development of chronic disease. This article identified the impact of prolonged TV watching along with other sedentary behaviors (e.g., computer use, less physically demanding occupations, video viewing, reading, sitting during long commutes, social inactivity) as possible cancer risk factors. This article quantitatively summarized the correlation between sedentary lives and cancer risk. TV watching has been the most commonly studied sedentary behavior associated with ingestion of unhealthy foods, leading to the potential to smoke and gain weight. Smoking and obesity are linked to an increased risk of cancer.