Since the Vietnam War ended in 1975, numerous studies have been conducted to determine if an association exists between Agent Orange exposure and certain disabling conditions, specifically cancer. Although a definite causal relationship has not yet been established, sufficient data associate Agent Orange with certain conditions. Because of their advancing age, similar to other baby boomers, Vietnam veterans are at a higher risk of developing malignancies. However, their exposure to Agent Orange also may increase their risk for cancer and other associated diseases. This article examines the latest findings of scientific research sponsored by the Department of Veterans Affairs and discusses the importance of well-informed oncology nurses when providing care for patients with cancer exposed to Agent Orange.