Seizures are common neurologic complications of cancer and can occur at any point in the disease trajectory. Despite this, the exact pathophysiologic basis of seizures related to cancer is not known. The etiology of seizures is thought to be multifactorial, including the presence of tumors within the cranial cavity, metabolic derangements, and the direct effect of medications on the central nervous system. Seizure management often employs anticonvulsant medications and interventions to promote patient safety. Oncology nurses must be aware of the potential seriousness of this complication and implement appropriate strategies to assist patients in maintaining safety and quality of life.