Quality & Safety

Applying the SEIPS Framework to Redesign Chemotherapy Desensitization Within the Intensive Care Unit

Muriel Moyo

Jennifer Cook

Maurice Espinoza

Jennifer Hoff

chemotherapy desensitization, intensive care unit, SEIPS framework
CJON 2024, 28(1), 89-93. DOI: 10.1188/24.CJON.89-93

Chemotherapy desensitization (CD) enables patients with allergic reactions to receive chemotherapy safely. However, ineffective workflows, delays, and communication gaps between the oncology unit and the intensive care unit can compromise patient care and satisfaction. Using the Systems Engineering Initiative for Patient Safety (SEIPS) framework, the CD workflow at an academic medical center was redesigned to facilitate interprofessional collaboration, role clarity, technology optimization, and effective communication. Fewer care delays and reported safety events were experienced postimplementation of the redesigned workflow, despite increased CD patient admissions.


  • Evaluating inefficiencies in the healthcare system workflow using the SEIPS framework facilitates workflow redesign and targeted improvements.
  • Clarifying roles, optimizing technology, communicating effectively, and collaborating interprofessionally can result in timelier care delivery.
  • The nurse navigator is a central role within the CD workflow.
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