Advanced Practice
NCPD Article

Herpes Simplex Virus Encephalitis

Silvia Hofmann

herpes simplex virus encephalitis, altered mental status, neurologic condition
CJON 2023, 27(3), 237-241. DOI: 10.1188/23.CJON.237-241

Herpes simplex virus (HSV) encephalitis (HSVE), which is caused by HSV-1 or HSV-2, is a rare neurologic disorder associated with focal or global cerebral dysfunction. HSVE is a syndrome of altered mental status, fever, and seizures. Advanced practice providers should have a high clinical suspicion of HSVE in any patient presenting with these symptoms to ensure prompt workup and administration of IV acyclovir to help minimize mortality and morbidity.

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