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Online Exclusive Article

Research Biopsies: An Integrative Review of the Experiences of Patients With Cancer

Elizabeth Abraham
Kathryn Post
Laura Spring
Giuliana Malvarosa
Elizabeth Tripp
Jeffrey M. Peppercorn
Aditya Bardia
Karleen Habin
CJON 2018, 22(3), E71-E77 DOI: 10.1188/18.CJON.E71-E77

Background: Research biopsies (RBs) are essential to understanding tumor biology and mechanisms of resistance and to advancing precision medicine. However, RBs have associated risks and may not benefit the patient.

Objectives: The purpose of this integrative review is to summarize and synthesize the current literature on the experience, attitudes, and understanding of patients with cancer related to RBs.

Methods: Articles from January 2010 to February 2017 were retrieved via a search of MEDLINE®. Articles included reported on the willingness, perceptions, understanding, attitudes, and/or experience of patients with cancer related to RBs.

Findings: Nine of 216 identified studies were selected. Studies exploring patient willingness to undergo RBs (n = 6) identified RBs as a potential barrier to clinical trial participation. Studies exploring patient understanding and informed consent (n = 3) revealed variable patient knowledge of the risks and benefits of RBs.

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