Please login (Members) to view content or
(Nonmembers) this article.
No votes yet
Advanced Practice

Oral Anticancer Agents: An Intervention to Promote Medication Adherence and Symptom Management

Sandra L. Spoelstra
Alla Sikorskii
Atreyee Majumder
Peggy S. Burhenn
Monica Schueller
Barbara Given
CJON 2017, 21(2), 157-160 DOI: 10.1188/17.CJON.157-160

Symptom burden and poor adherence to oral anticancer agents remain significant clinical problems. This study examined feasibility, preliminary efficacy, and satisfaction with ADHERE, a nurse practitioner intervention that promotes symptom management and adherence among patients prescribed oral agents. The intervention group (which received one semistructured, face-to-face session followed by three weekly telephone sessions using motivational interviewing, brief cognitive-behavioral therapy, and a toolkit to promote self-management) had significantly lower symptom severity postintervention. Self-reported adherence was high and did not differ by group. Patients reported being highly satisfied with the ADHERE intervention.


  • No known standard of care exists for patients newly prescribed oral anticancer agents.
  • Many patients with cancer treated with oral anticancer agents have difficulty managing side effects of treatment, which may lead to difficulty with adherence to the medication regimen, or adverse events.
  • The intervention improved symptom severity compared to the control group.

Members Only

Access to this article is restricted. Please login to view the full article.

Not a current ONS Member or journal subscriber?
Join/Renew Membership or