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December 2014, Supplement to Volume 18, Number 6
Putting Evidence Into Practice:
Evolving Evidence for Treatment and Management From 2009–2014
Mei R. Fu, PhD, RN, ACNS-BC, FAAN, Jie Deng, PhD, RN, OCN®, and Jane M. Armer, PhD, RN, FAAN
Cancer-related lymphedema is a progressive and chronic syndrome of abnormal swelling and multiple symptoms resulting from cancer treatment. Even with modern medical advances, lymphedema remains a major health problem affecting thousands of cancer survivors. To provide healthcare professionals with evidence-based clinical practice guidelines for lymphedema treatment and management, a systematic review was conducted to evaluate 75 selected articles from 2009–2014 by the Oncology Nursing Society Putting Evidence Into Practice lymphedema team. Findings of the systematic review support complete decongestive therapy, compression bandages, and compression garments with highest evidence for best clinical practice. Weight management, full-body exercise, information provision, prevention, and early intervention protocols are likely to be effective for clinical practice. Historic recommendations for activity restriction and avoidance of aerobic and resistive exercises that limit cancer survivors’ daily lives have been challenged with more evidence. Cancer survivors may not need to restrict activities such as resistive or aerobic exercises and weightlifting with gradual exercise progression. Future research should focus on providing high-level evidence using randomized clinical trials with larger samples and studying lymphedema beyond breast cancer.
About 12.7 million people have been diagnosed with cancer worldwide, and the global burden of cancer is expected to increase largely because of aging and growth of the world population (Jemal et al., 2011). In 2008, the cost of cancer worldwide, including disability, was estimated to be $895 billion (American Cancer Society, 2014). With improved cancer survival, management of late effects and long-term survivorship issues have become more important.
Cancer-related lymphedema is a late effect that often develops 1–5 years or even 20 years after cancer treatment (McLaughlin et al., 2008; Paskett, Naughton, McCoy, Case, & Abbott, 2007; Petrek, Senie, Peters, & Rosen, 2001). Cancer-related lymphedema is a progressive and chronic syndrome of abnormal swelling and multiple symptoms resulting from the accumulation of lymph fluid from the obstruction or disruption of the lymphatic system associated with cancer treatment such as surgery or radiation (Fu & Rosedale, 2009; Johansson, Ohlsson, Ingvar, Albertsson, & Ekdahl, 2002; Stanton, Modi, Mellor, Levick, & Mortimer, 2009). The most perplexing aspect of this late effect of cancer treatment is that lymphedema can occur even after less invasive surgical procedures such as sentinel lymph node biopsy or partial mastectomy (McLaughlin et al., 2013). Lymphedema affects as many as 40% of the 2.9 million women treated for breast cancer in the United States (McLaughlin et al., 2008; Paskett et al., 2007). Globally, about 1.4 million women are diagnosed with breast cancer each year, accounting for 23% of all diagnosed cancers in women (Ferlay et al., 2010). Even more distressing is that all of the women treated for cancer are facing a lifetime risk of developing lymphedema. In addition, lymphedema affects a large proportion of cancer survivors with a variety of malignancies, including gynecologic cancer (20%), melanoma (16%), genitourinary cancer (10%), and head and neck cancer (4%) (Cormier et al., 2010).
Because no current surgical or medical interventions exist, lymphedema remains a major health issue. Significantly lower quality of life is observed in cancer survivors with lymphedema than in those without it (Langer et al., 2007; McLaughlin et al., 2008). Treatment and management of lymphedema is, in most cases, palliative with a goal of preventing disease progression and alleviation of symptoms. Routine checkups for lymphedema management; long-term physical therapy; self-management and equipment (e.g., compression garments, bandages, special lotions); and repeated cellulitis, infections, and lymphangitis create financial and economic burdens not only to cancer survivors, but also to the healthcare system (Fu & Rosedale, 2009; Shih et al., 2009). For example, lymphedema is a significant source of biomedical expenditures for cancer survivors, increasing treatment costs by more than $10,000 annually (Shih et al., 2009). In addition, cancer survivors with lymphedema spend more days annually either hospitalized or visiting physicians’ offices; they also are absent from work more often, which could adversely affect employment (Shih et al., 2009).
To provide healthcare professionals with evidence-based clinical practice guidelines for lymphedema treatment and management, the Oncology Nursing Society (ONS) Putting Evidence Into Practice (PEP®) lymphedema team conducted a systematic review in 2007 (Poage, Singer, Armer, Poundall, & Shellabarger, 2008). The review revealed common limitations in many studies from 1997–2007, including small sample sizes, lack of randomized control groups, imprecise intervention standardization within and across groups, imprecise or diverse measurement approaches, and limited follow-up. Complete decongestive therapy (CDT), compression garments and bandaging alone, and infection treatment were recommended for practice. However, the review also cautioned that the rigors of CDT may pose considerable challenges for patients and clinicians because of the multiple components of the treatment and access to trained lymphedema therapists.
With the enhanced realization that lymphedema is part of a progressive and chronic syndrome, researchers and clinicians have attempted to conduct more rigorous studies and explore a variety of treatment and management strategies for lymphedema. Under the leadership of the ONS PEP project, the lymphedema team continually reviews, evaluates, and updates treatment and management evidence on cancer-related lymphedema. The purpose of this article is to report the updated evidence for current treatment and management of cancer-related lymphedema through February 2014.
This systematic review was a continuing effort of the previous review of literature from 1997–2007 where 218 articles were extracted from five databases, and 57 articles were reviewed and evaluated (Poage et al., 2008). The current review was conducted from January 2009 through February 2014. To capture all literature potentially related to lymphedema, a broad range of key search terms listed in Figure 1 were applied to major medical indices: PubMed, MEDLINE®, CINAHL®, Cochrane Library databases, the National Library of Medicine’s database, and CancerLit.
A total of 880 articles were retrieved: 732 articles were excluded because they did not meet the inclusion criteria, and 148 articles were selected for full article review based on inclusion and exclusion criteria listed in Figure 2. Each article was summarized and assessed independently by a member of the ONS PEP lymphedema team and then reviewed by a second member of the team to ensure appropriate and accurate representation of the material. Next, the team selected 75 articles based on inclusion and exclusion criteria and categorized the evidence using the research grading system from the ONS PEP level of evidence guidelines (Johnson, 2014; Mitchell & Friese, n.d.). This process was facilitated by ONS research associates. Consensus was achieved among the members of the ONS PEP lymphedema team by applying the PEP categorization of evidence (see Table 1 page 1 and page 2).
Levels of Evidence
Recommended for Practice
Complete decongestive therapy: CDT includes manual lymph drainage; multilayer, short-stretch compression bandaging; gentle exercise; meticulous skin care; education in lymphedema self-management; and elastic compression garments. CDT was recommended for lymphedema treatment and management upon review and evaluation of nine primary research articles and five systematic reviews on the effectiveness of CDT. The strengths of the existing literature from 2009–2014 include two randomized clinical trials (RCTs) with comparatively larger samples and the defined CDT outcome of limb volume reduction.
Haghighat et al. (2010) randomized 109 breast cancer survivors with postmastectomy lymphedema into CDT alone or CDT plus pneumatic compression therapy and followed the patients for three months. CDT alone had better results, with 16.9% limb volume reduction compared to 7.5% reduction with CDT plus pneumatic compression therapy. Dayes et al. (2013) conducted a multisite RCT and assigned 95 breast cancer survivors, with lymphedema defined as increased arm volume of 10%, to manual lymph drainage (MLD) plus bandaging and compression garments or compression garments only. The study showed that reduction in arm volume was similar in both groups, but increased volume loss was reported with MLD plus bandaging and compression garments at a one-year follow-up. However, the study lost more than 10% of patients using compression garments only.
The remaining seven studies were quasiexperimental, observational, or retrospective (Carmeli & Bartoletti, 2011; de Godoy & Godoy, 2013; Hwang, Hwang, Kim, et al., 2013; Hwang, Jeong, Kim, & Sim, 2013; Liao et al., 2013; Randheer et al., 2011; Vignes, Blanchard, Arrault, & Porcher, 2013). In a prospective quasiexperimental study, 35 breast cancer survivors with lymphedema had statistically significant limb volume reduction after CDT intensive therapy (four times weekly) (p < 0.001), but skin irritation after bandaging was reported (Randheer et al., 2011). All of the studies were conducted among breast cancer survivors with lymphedema except for two. Hwang, Hwang, et al. (2013) conducted an observational study on CDT among 22 patients with upper- and lower-limb lymphedema associated with different cancers and found significant volume reduction in the upper and lower limbs after CDT. Carmeli and Bartoletti (2011) used a retrospective design to evaluate CDT among 12 melanoma survivors with lower-limb lymphedema. Findings of the study showed that baseline to post-CDT limb volume reduced 17% below baseline at the two-year follow-up (p = 0.05).
Findings from the five systematic reviews conducted from 2009–2013 varied in terms of levels of evidence (Beck, Wanchai, Stewart, Cormier, & Armer, 2012; Lasinski et al., 2012; Leal, Carrara, Vieira, & Ferreira, 2009; Ridner, Fu, et al., 2012; Rodrick et al., 2014). Lasinski et al. (2012) evaluated 27 studies and case series on the effectiveness of CDT and its components and concluded that CDT was effective in limb volume reduction, but individual component contributions were unclear. Beck et al. (2012) reviewed 11 studies to evaluate the effectiveness of CDT as palliative care and concluded that the level of effectiveness for CDT, MLD, and compression therapy was not established in the field of palliative care. The most recent review of 22 articles reported that CDT plus Kinesio taping was likely to be effective (Rodrick et al., 2014). Ridner, Fu, et al. (2012) evaluated 16 studies on the effectiveness of CDT as self-care and concluded that CDT as self-care and whole-body exercise were likely to be effective. The five systematic reviews reported the limitations of the existing studies, including small sample sizes and inconsistency in treatment and outcome protocols.
Compression bandaging and compression garments: Compression bandaging and compression garments that provide external compression are important components of CDT. Compression bandaging uses inelastic or low-stretch bandages to produce a massaging effect and stimulate lymph flow. Compression garments (hosiery) are custom-made or ready-to-use elastic garments that provide 20–40 mmHg pressure to promote lymph flow. The time, effort, and dexterity required for bandaging can become burdensome and is not practical or possible for some patients, necessitating the use of an alternative compression method, such as compression garments. Four RCTs were identified that evaluated the comparative effectiveness of compression bandaging and compression garments; arm volume reduction with different bandage pressures; and comparison of low-stretch compression dressings and alginate semirigid bandages (Damstra & Partsch, 2009; Kasseroller & Brenner, 2010; King, Deveaux, White, & Rayson, 2012; Sawan, Mugnai, Lopes Ade, Hughes, & Edmondson, 2009). One systematic review was identified (McNeely, Peddle, Yurick, Dayes, & Mackey, 2011).
A small RCT demonstrated no significant difference between arm volume reduction after two weeks among breast cancer survivors with lymphedema (n = 25) who wore compression bandaging plus MLD and compression garments plus MLD (King et al., 2012). Another RCT evaluated bandage pressure among 36 breast cancer survivors with lymphedema and demonstrated no significant differences in arm volume reduction with different bandage pressure; however, nonelastic multilayer compression bandages with 20–30 mmHg pressure were better tolerated (Damstra & Partsch, 2009). The third RCT placed 61 breast cancer survivors with lymphedema into low-stretch compression dressings or alginate semirigid bandages (Kasseroller & Brenner, 2010). Overall, no significant difference was found in terms of arm volume reduction between the two groups, but participants in the semirigid bandage group had significantly better comfort (p < 0.025). Sawan et al. (2009) conducted a small RCT among vulva cancer survivors with lower-limb lymphedema post-inguinofemoral lymphadenectomy (n = 14) into supportive care with or without the use of graduated compression stockings for six months. Patients using graduated compression stockings had less increase in leg volume, better clinical performance, and fewer leg symptoms (p < 0.05). However, noncompliance and dropouts further reduced the sample size. One systematic review plus meta-analysis (McNeely et al., 2011) from 25 studies of 1,018 breast cancer survivors with lymphedema concluded that moderate evidence supports the effectiveness of compression garments and bandaging in reducing limb volume. The systematic review cautioned about the poor quality of the reviewed studies. The findings from these studies and the systematic review suggest that, in cancer survivors with lymphedema, compression bandaging and compression garments are beneficial, but more RCTs are needed with larger sample sizes and patients treated for different cancers.
Likely to Be Effective
Weight management: No new studies have been published on weight management since 2009. As a result, the evidence for weight management focusing on reduction of body mass index or weight continues to be likely to be effective for lymphedema treatment and management (Poage et al., 2008).
Full-body exercise: A total of 11 new primary research studies and 3 systematic reviews were identified. Among the 11 primary research articles, 9 were RCTs and 2 were quasiexperimental with pre- and post-test and comparative studies. All of the studies were conducted in breast cancer survivors experiencing lymphedema.
Jeffs and Wiseman (2013) randomized 23 breast cancer survivors with lymphedema into a treatment group of home-based exercise plus standard self-care or a control group of self-care alone. Significant arm volume reduction was found in the treatment group with 55% adherence and no arm volume reduction in the control group at the 26-week follow-up. A single-blind multisite RCT assigned 82 breast cancer survivors without lymphedema to a treatment group of structured exercise and education sessions or a control group of education alone (Anderson et al., 2012). No significant changes were found in arm volume, but participants in the treatment group had better six-minute walk results (p < 0.05). A single-site blinded RCT placed 32 breast cancer survivors with lymphedema into a treatment group of therapist-supervised exercises or a control group of supportive coping education; it showed significant beneficial effects of treatment group in terms of bioelectrical impedance measurements (McClure, McClure, Day, & Brufsky, 2010).
A single-blind RCT assigned 29 breast cancer survivors with lymphedema to a treatment group of a water-based exercise program or a control group of no exercise (Johansson, Hayes, Speck, & Schmitz, 2013). Twenty-five percent of participants in the treatment group did not complete the intervention. No significant difference was found in lymphedema status between groups; however, shoulder mobility was significantly better in the exercise group (p < 0.05). Another RCT put 38 patients treated for breast cancer into a treatment group of a Nordic walking program (two sessions of a 60-minute walk for eight weeks) or a control group of no walking (Malicka et al., 2011). Among the 38 participants, 34% had lymphedema. No significant differences were found between groups in arm volume, and the treatment group showed no increase in arm volume.
An RCT placed 40 breast cancer survivors into CDT with or without active resistive exercises, such as shoulder-stretching exercises followed by using dumbbells for 15 minutes, while wearing a compression stocking or multilayer bandage supervised by physical therapists five days per week for two weeks (Kim, Sim, Jeong, & Kim, 2010). Significant proximal arm volume reduction was noted in those in the active resistive exercise group (p < 0.05), but no statistical significant reduction was found in the distal or overall arm volume. No significant difference was found in arm volume in another RCT that put 32 breast cancer survivors with lymphedema into a treatment group of 12-week aerobic and resistance exercise with a control group (Hayes, Reul-Hirche, & Turner, 2009).
A quasiexperimental study with a pre- and post-test design on the effect of home-based exercise among 32 breast cancer survivors with lymphedema demonstrated significant reduction in arm circumference and limb volume (p < 0.001) (Gautam, Maiya, & Vidyasagar, 2011). Another pre- and post-test quasiexperimental study of 26 breast cancer survivors with lymphedema found no significant changes in arm volume after pole-walking (Jonsson & Johansson, 2009). A comparative study of 83 breast cancer survivors on the effect of postoperative physical therapist–supervised exercise and home exercise demonstrated that patients receiving supervised exercise had better arm mobility and function (p < 0.001) and less lymphedema (p = 0.036) at a six-month follow-up (Scaffidi et al., 2012).
One systematic review of 24 RCTs in breast cancer survivors with lymphedema yielded no evidence of negative effect of upper-extremity exercise on upper-limb lymphedema (McNeely et al., 2010). Another systematic review of six RCTs on the effectiveness of exercise programs on shoulder mobility and lymphedema incidence with 429 women treated for breast cancer showed that early shoulder exercise did not increase lymphedema incidence but prevented deterioration of shoulder mobility (Chan, Lui, & So, 2010). In addition, a review of 10 studies concluded that resistance, aerobic, and other exercises were effective for lymphedema management (Kwan, Cohn, Armer, Stewart, & Cormier, 2011).
Taken together, the findings from these studies and systematic reviews suggest that full-body exercise, particularly in breast cancer survivors, was not associated with an increase in arm volume and may have helped improve shoulder mobility.
Information provision: The importance of patient education that provides lymphedema information and risk-reduction strategies has been recognized by patients and professional organizations (Fu & Rosedale, 2009). In practice, many women treated for breast cancer do not recall being offered any lymphedema information or risk-reduction strategies (Fu, Chen, Haber, Guth, & Axelrod, 2010). A study of 136 breast cancer survivors demonstrated that patients who received lymphedema information reported significantly fewer symptoms and more practice of risk-reduction behaviors than those who did not. After controlling for confounding factors of treatment-related risk factors, patient education remains an important predictor of lymphedema outcome (Fu et al., 2010).
Prevention and early intervention protocols: A single-site blinded trial randomized 116 Spanish patients treated for breast cancer into an experimental group of an early physiotherapy program for reducing lymphedema risk or a control group (Torres Lacomba et al., 2010). The limb volumes of the affected arm increased over time among the participants in the control and intervention groups, but significantly fewer participants (7%) in the intervention group had lymphedema compared to those in the control group (25%) (p = 0.01). In terms of interlimb differences, the average limb volume in the affected arm was greater than the volume in the unaffected arm in the control and intervention groups. However, the interlimb differences of the affected arm were less in the participants in the intervention group (1.6%) than those in the control group (5.1%) (p = 0.00). Overall, early physiotherapy had a longer protective effect for participants in the intervention group, and lymphedema emerged more quickly in the control group.
In a small RCT, Boccardo et al. (2009) placed 49 women treated for breast cancer into an experimental group of prevention and early intervention with preoperative lymphscintigraphy, risk minimization via surgical techniques (n = 25), and early use of elastic sleeves or a control group (n = 24). At 12- and 24-month follow-ups, participants in the experimental group had a lower incidence of arm volume increases (p < 0.04). Of the 49 women with unilateral breast cancer surgery who were measured at 24 months, 10 (21%) had lymphedema, with 8% in the experimental group and 33% in control group. At 12 and 24 months, the number of patients with arm volume increases was significantly lower in the experimental group (p = 0.03). Taken together, the studies suggest that prevention and early intervention protocols are likely to be effective.
Benefits Balance With Harms
Activity restriction and lifting weights: Four RCTs were conducted on the effects of activity restriction and lifting weights on lymphedema. A single-blind and multisite RCT in Norway assigned women after breast cancer surgery to groups with no activity restrictions or activity restrictions (Sagen, Karesen, & Risberg, 2009). Participants with no activity restrictions had a supervised physical therapy program in an outpatient clinic, which emphasized progressive resistance training two to three times per week; they also received standard detailed information on the unrestricted program. Participants with activity restrictions were told to restrict the use of the affected limb for six months, including avoidance of aerobic or other types of exercise involving heavy upper-limb activity, and to avoid carrying or lifting items weighing more than 3 kg. They also were instructed on passive techniques emphasizing flexibility and light massage. At the two-year follow-up, 13% of patients in each group had arm lymphedema, and no significant differences were found in the incidence of developing lymphedema between the groups. Findings suggest that activity restriction does not result in improved outcomes.
An RCT of an equivalence trial on physical activity and lymphedema placed 134 breast cancer survivors at risk for lymphedema into a weightlifting intervention, which included a gym membership and 13 weeks of supervised instruction followed by 9 months unsupervised, or a control group of no exercise (Schmitz et al., 2010). After two sessions of completing three sets of 10 repetitions with no change in arm symptoms, weights were increased for each exercise by the smallest possible increment. At the 12-month follow-up, onset of lymphedema (5% or more increase in interlimb volume difference during the 12 months) was 17% (13 of 75) in the control group and 11% (8 of 72) in the weightlifting group. The findings demonstrated that slowly progressive weightlifting did not increase the risk of lymphedema in breast cancer survivors.
A single-blind RCT in Australia randomly assigned 60 breast cancer survivors with lymphedema into one of three groups: low- or high-load resistance exercise or a wait-list usual care control group (Cormie, Galvão, Spry, & Newton, 2013). Participants in the low- and high-load exercise groups were instructed and supervised by an exercise physiologist to perform six exercises targeting the major upper-body muscle groups. The intensity of the exercises was measured on the Borg scale as moderate to high. Participants were supervised to perform the exercises once a week for 60 minutes for three months. During each exercise session, participants had the choice of whether to wear compression garments. Patients were encouraged to continue their lymphedema care and routine daily activity. At the three-month follow-up, physical-functioning measurement showed significant improvement in both exercise groups compared to the control group, which showed a decline in physical functioning (p = 0.04). Twenty-five percent of participants wore compression garments during exercise. Findings show that breast cancer survivors with lymphedema can safely lift weights at low- and high-relative loads. Moderate- to high-intensity exercise may be beneficial to improve physical functioning (p = 0.001).
Another randomized crossover study in Australia (Cormie, Pumpa, et al., 2013) assigned 17 breast cancer survivors with lymphedema to low- or high-load exercises involving moderate to high intensity first and then, after a 10–12 day washout period, crossed over to the other load condition. Patients were instructed and supervised by an exercise physiologist to perform high-load exercise (i.e., to lift as much weight as possible for 15–20 repetitions) or low-load exercise (i.e., to lift as much weight as possible for six to eight repetitions). Patients had the option to wear compression garments during exercise. Arm volume or circumference was measured before exercise, immediately after exercise, and 24 and 72 hours after each exercise session. Patients were instructed to continue their usual lymphedema care and physical activities. No significant changes were found in arm volume or circumference of the affected arm before and immediately after each exercise session, no significant changes were noted across most time points, and no significant differences were identified between high- and low-load exercises. In addition, no significant differences were reported in severity of pain, heaviness, or tightness across all study time points. Findings of the study show that neither low- nor heavy-load resistance upper-body exercises had any acute impact on lymphedema measurement and symptoms.
The current research provides the evidence that activity restriction is unlikely to improve lymphedema outcomes and that weightlifting and high- or low-load resistance exercise can be safe for breast cancer survivors with lymphedema.
Kinesio tape bandage: Kinesio tape, or K-tape, is made of 100% cotton fibers with acrylic heat-sensitive glue. A single-blind RCT in Taiwan placed breast cancer survivors with lymphedema into standard decongestive lymphatic therapy combined with pneumatic compression (n = 40) and modified decongestive lymphatic therapy, in which the use of a short-stretch bandage is replaced with Kinesio tape (n = 20) (Tsai, Hung, Yang, Huang, & Tsauo, 2009). At the three-month follow-up, no significant difference was reported between groups in terms of arm circumference and limb volume by water displacement (p > 0.05). Compared to bandaging, Kinesio tape was accepted by patients more because the patients did not need to bandage themselves; in addition, Kinesio tape was less difficult, more comfortable, and more convenient to use (p < 0.05). However, more patients who used Kinesio tape had wounds compared to patients who used bandaging (p < 0.05). Kinesio tape may be an alternative choice for patients who have difficulty using short-stretch bandaging. Care with skin integrity is essential with the use of Kinesio tape.
Effectiveness Not Established
Manual lymph drainage: One RCT with 90 advanced stage cancer survivors with lymphedema (Clemens, Jaspers, Klaschik, & Nieland, 2010) and a descriptive study of 682 breast cancer survivors with lymphedema (Vignes, Porcher, Arrault, & Dupuy, 2011) demonstrated no significant effect of manual lymph drainage alone on treating lymphedema. An RCT of 154 breast cancer survivors (Devoogdt et al., 2011) and another RCT of 58 breast cancer survivors (Martin, Hernandez, Avendano, Rodrigues, & Martinez, 2011) demonstrated no significant effect of MLD alone on preventing lymphedema. A small prospective trial of 67 breast cancer survivors showed that women in the control group without MLD had a statistically significant increase of 16 ml in arm volume compared to a group with MLD alone (Zimmermann, Wozniewski, Szklarska, Lipowicz, & Szuba, 2012).
Low-level laser therapy: A small randomized, double-blind, placebo-controlled trial of 50 breast cancer survivors with lymphedema showed significant volume reduction in a low-level laser group compared to a control group with traditional lymphedema therapy in Egypt (Ahmed Omar, Abd-El-Gayed Ebid, & El Morsy, 2011). No further evidence to support the use of low-level laser was found in two other studies that evaluated the effect of adding low-level laser therapy to traditional lymphedema therapy (Dirican et al., 2011) or intermittent use of a pneumatic compression device (Kozanoglu, Basaran, Paydas, & Sarpel, 2009).
Pneumatic compression: One larger RCT in Iran (N = 112) (Haghighat et al., 2010) and a small RCT (N = 36) in the United States (Fife, Davey, Maus, Guiliod, & Mayrovitz, 2012) demonstrated no significant effect of a pneumatic compression device alone in treating breast cancer–related lymphedema in terms of arm volume reduction among breast cancer survivors with lymphedema. In addition, Fife et al. (2012) reported adverse events that were considered to be possibly or definitely pneumatic compression device–related, including increased arm swelling, breast inflammation, pain, fibrosis and infection, increased hand swelling, arm pain, finger numbness, increased swelling of torso, pain in axilla and back in the standard device group, and increased swelling of the lymph nodes in the contralateral axilla in the advanced device group; however, the researchers did not report the exact prevalence of the adverse events. In a small pre- and post-test study of 21 breast cancer survivors with lymphedema, Moattari et al. (2012) reported a significant effect of combined CDT and pneumatic compression device on arm volume reduction (p < 0.05).
A small RCT in the United States assigned 42 breast cancer survivors with lymphedema into an experimental group receiving truncal, chest, and arm pneumatic compression to treat lymphedema and a control group of arm compression only (Ridner, Murphy, et al., 2012). Findings demonstrated no significant effect of the pneumatic compression device on lymphedema symptoms, bioimpedance ratio, and physical functioning.
No new research was published on nanocrystalline silver dressing on lymphatic ulcers and aromatherapy. Current published literature did not provide supporting evidence to change the level of evidence for hyperbaric oxygen (Gothard et al., 2010), acupuncture (Cassileth et al., 2011, 2013), varied surgical techniques (Boccardo et al., 2009, 2011; Damstra, Voesten, van Schelven, & van der Lei, 2009), liposuction (Schaverien, Munro, Baker, & Munnoch, 2012), and lymphatic venous anastamosis (Boccardo et al., 2011; Cormier, Rourke, Crosby, Chang, & Armer, 2012; Damstra et al., 2009).
New emerging treatments were under investigation, including aquatherapy (Johansson et al., 2013; Tidhar & Katz-Leurer, 2010), axillary reverse mapping (Boneti et al., 2012), cell transplantation (Maldonado et al., 2011), massage (Maher, Refshauge, Ward, Paterson, & Kilbreath, 2012), qigong (Fong et al., 2014), the use of a device delivering electronic sound waves and vacuum (Cavezzi, Paccasassi, & Elio, 2013), extracorporeal shockwave therapy (Bae & Kim, 2013), use of a mechanical exercise device (Bordin, Guerreiro Godoy, & Pereira de Godoy, 2009; Guerreiro Godoy, Guimaraes, Oliani, & Pereira de Godoy, 2011; Guerreiro Godoy, Oliani, & Pereira de Godoy, 2010; Guerreiro Godoy, Pereira, Oliani, & Pereira de Godoy, 2012), low-intensity electrostatic stimulation (Belmonte et al., 2012), and lumbar sympathetic ganglion block (Woo, Park, Kim, & Kim, 2013).
Skin hygiene and care, compression garments when flying, and avoidance of blood pressure and venipuncture remain at the level of expert opinion.
Not Recommended for Practice
Drug therapy (the use of diuretics and benzopyrones) remains at the level of not recommended for practice.
Conclusion and Implications for Future Research
This systematic review supports the application of CDT, compression bandages, and compression garments with the highest evidence for clinical best practice for lymphedema. Nurses can advocate for the use of CDT and compression for their patients with lymphedema with the patients themselves and with other healthcare practitioners. Weight management, full-body exercise, information provision, and prevention and early intervention protocols are likely to be effective. New emerging treatments have been under investigation for this chronic and incurable condition, which is encouraging. Historic recommendations for activity restriction and avoidance of weightlifting that limit cancer survivors’ daily lives have been challenged with more evidence. Although more RCTs were conducted, the majority of the literature from 2009–2013 has similar limitations as the literature from 1997–2007: small sample sizes, homogeneity of breast cancer survivor samples, and lack of RCTs. Future research should focus on providing a high level of evidence using RCTs with larger samples and RCTs on lymphedema associated with other cancers.
Nurses should educate all patients and families at risk for lymphedema about risk-reduction and prevention methods. Nurses should also be prepared to provide access to further resources on request. Figure 3 provides a list of clinical resources for lymphedema care. In addition, nurses can advocate for health policy coverage for effective interventions that reduce lymphedema risk and assist in management.
Implications for Practice
Ø Recommend lymphedema interventions with the highest evidence for best clinical practice, such as complete decongestive therapy consisting of compression garments, bandaging, exercise, meticulous skin care, and manual lymphatic drainage by trained therapists, as well as compression bandaging and compression garments alone.
Ø Provide information on lymphedema, early detection, and early interventions to reduce risk or prevent progression.
Ø Understand the weight of evidence for potentially helpful lymphedema interventions and interpret research findings for patients and families in an accessible language and format.
The authors gratefully acknowledge Margaret Irwin, RN, PhD, for leading the Oncology Nursing Society PEP® Project, Kerri A. Moriarty, MLS, for her administrative support, and Marcia Beck, RN, ACNS, BC, CLT-LANA, Karen Giamichio, RN, BSN, MSN, and Lee Ann Johnson, MSN, RN, for participation in the systematic review.
Ahmed Omar, M.T., Abd-El-Gayed Ebid, A., & El Morsy, A.M. (2011). Treatment of post-mastectomy lymphedema with laser therapy: Double blind placebo control randomized study. Journal of Surgical Research, 165, 82–90. http://dx.doi.org/10.1016/j.jss.2010.03.050
American Cancer Society. (2014). Cancer facts and figures, 2014. Atlanta, GA: Author.
Anderson, R.T., Kimmick, G.G., McCoy, T.P., Hopkins, J., Levine, E., Miller, G., . . . Mihalko, S.L. (2012). A randomized trial of exercise on well-being and function following breast cancer surgery: The RESTORE trial. Journal of Cancer Survivorship: Research and Practice, 6, 172–181. http://dx.doi.org/10.1007/s11764-011-0208-4
Bae, H., & Kim, H.J. (2013). Clinical outcomes of extracorporeal shock wave therapy in patients with secondary lymphedema: A pilot study. Annals of Rehabilitation Medicine, 37, 229–234. http://dx.doi.org/10.5535/arm.2013.37.2.229
Beck, M., Wanchai, A., Stewart, B.R., Cormier, J.N., & Armer, J.M. (2012). Palliative care for cancer-related lymphedema: A systematic review. Journal of Palliative Medicine, 15, 821–827. http://dx.doi.org/10.1089/jpm.2011.0494
Belmonte, R., Tejero, M., Ferrer, M., Muniesa, J.M., Duarte, E., Cunillera, O., & Escalada, F. (2012). Efficacy of low-frequency low-intensity electrotherapy in the treatment of breast cancer-related lymphoedema: A cross-over randomized trial. Clinical Rehabilitation, 26, 607–618. http://dx.doi.org/10.1177/0269215511427414
Boccardo, F.M., Ansaldi, F., Bellini, C., Accogli, S., Taddei, G., Murdaca, G., . . . Campisi, C. (2009). Prospective evaluation of a prevention protocol for lymphedema following surgery for breast cancer. Lymphology, 42, 1–9.
Boccardo, F.M., Casabona, F., Friedman, D., Puglisi, M., De Cian, F., Ansaldi, F., & Campisi, C. (2011). Surgical prevention of arm lymphedema after breast cancer treatment. Annals of Surgical Oncology, 18, 2500–2505. http://dx.doi.org/10.1245/s10434-011-1624-4
Boneti, C., Badgwell, B., Roberston, Y., Korourian, S., Adkins, L., & Klimberg, V. (2012). Axillary reverse mapping (ARM): Initial results of phase II trial in preventing lymphedema after lymphadenectomy. Minerva Ginecologica, 64, 421–430.
Bordin, N.A., Guerreiro Godoy, M.F., & Pereira de Godoy, J.M. (2009). Mechanical lymphatic drainage in the treatment of arm lymphedema. Indian Journal of Cancer, 46, 337–339. http://dx.doi.org/10.4103/0019-509X.55556
Carmeli, E., & Bartoletti, R. (2011). Retrospective trial of complete decongestive physical therapy for lower extremity secondary lymphedema in melanoma patients. Supportive Care in Cancer, 19, 141–147. http://dx.doi.org/10.1007/s00520-009-0803-3
Cassileth, B.R., Van Zee, K.J., Chan, Y., Coleton, M.I., Hudis, C.A., Cohen, S., & Vickers, A.J. (2011). A safety and efficacy pilot study of acupuncture for the treatment of chronic lymphoedema. Acupuncture in Medicine, 29, 170–172. http://dx.doi.org/10.1136/aim.2011.004069
Cassileth, B.R., Van Zee, K.J., Yeung, K.S., Coleton, M.I., Cohen, S., Chan, Y.H., . . . Hudis, C.A. (2013). Acupuncture in the treatment of upper-limb lymphedema: Results of a pilot study. Cancer, 119, 2455–2461. http://dx.doi.org/10.1002/cncr.28093
Cavezzi, A., Paccasassi, S., & Elio, C. (2013). Lymphedema treatment by means of an electro-medical device based on bioresonance and vacuum technology: Clinical and lymphoscintigraphic assessment. International Angiology, 32, 417–423.
Chan, D.N., Lui, L.Y., & So, W.K. (2010). Effectiveness of exercise programmes on shoulder mobility and lymphoedema after axillary lymph node dissection for breast cancer: Systematic review. Journal of Advanced Nursing, 66, 1902–1914. http://dx.doi.org/10.1111/j.1365-2648.2010.05374.x
Clemens, K.E., Jaspers, B., Klaschik, E., & Nieland, P. (2010). Evaluation of the clinical effectiveness of physiotherapeutic management of lymphoedema in palliative care patients. Japanese Journal of Clinical Oncology, 40, 1068–1072.
Cormie, P., Galvão, D.A., Spry, N., & Newton, R.U. (2013). Neither heavy nor light load resistance exercise acutely exacerbates lymphedema in breast cancer survivor. Integrative Cancer Therapies, 12, 423–432. http://dx.doi.org/10.1177/1534735413477194
Cormie, P., Pumpa, K., Galvão, D.A., Turner, E., Spry, N., Saunders, C., . . . Newton, R.U. (2013). Is it safe and efficacious for women with lymphedema secondary to breast cancer to lift heavy weights during exercise: A randomised controlled trial. Journal of Cancer Survivorship: Research and Practice, 7, 413–424.
Cormier, J.N., Askew, R.L., Mungovan, K.S., Xing, Y., Ross, M.I., & Armer, J.M. (2010). Lymphedema beyond breast cancer: A systematic review and meta-analysis of cancer-related secondary lymphedema. Cancer, 116, 5138–5149. http://dx.doi.org/10.1002/cncr.25458
Cormier, J.N., Rourke, L., Crosby, M., Chang, D., & Armer, J.M. (2012). The surgical treatment of lymphedema: A systematic review of the contemporary literature (2004–2010). Annals of Surgical Oncology, 19, 642–651. http://dx.doi.org/10.1245/s10434-011-2017-4
Damstra, R.J., & Partsch, H. (2009). Compression therapy in breast cancer-related lymphedema: A randomized, controlled comparative study of relation between volume and interface pressure changes. Journal of Vascular Surgery, 49, 1256–1263.
Damstra, R.J., Voesten, H.G., van Schelven, W.D., & van der Lei, B. (2009). Lymphatic venous anastomosis (LVA) for treatment of secondary arm lymphedema. A prospective study of 11 LVA procedures in 10 patients with breast cancer related lymphedema and a critical review of the literature. Breast Cancer Research and Treatment, 113, 199–206. http://dx.doi.org/10.1007/s10549-008-9932-5
Dayes, I.S., Whelan, T.J., Julian, J.A., Parpia, S., Pritchard, K.I., D’Souza, D.P., . . . Levine, M.N. (2013). Randomized trial of decongestive lymphatic therapy for the treatment of lymphedema in women with breast cancer. Journal of Clinical Oncology, 31, 3758–3763. http://dx.doi.org/10.1200/JCO.2012.45.7192
de Godoy, J.M., & Godoy, M.F. (2013). Evaluation of a new approach to the treatment of lymphedema resulting from breast cancer therapy. European Journal of Internal Medicine, 24, 59–62. http://dx.doi.org/10.1016/j.ejim.2012.08.008
Devoogdt, N., Christiaens, M.R., Geraerts, I., Truijen, S., Smeets, A., Leunen, K., . . . Van Kampen, M. (2011). Effect of manual lymph drainage in addition to guidelines and exercise therapy on arm lymphoedema related to breast cancer: Randomised controlled trial. BMJ, 343, d5326. http://dx.doi.org/10.1136/bmj.d5326
Dirican, A., Andacoglu, O., Johnson, R., McGuire, K., Mager, L., & Soran, A. (2011). The short-term effects of low-level laser therapy in the management of breast-cancer-related lymphedema. Supportive Care in Cancer, 19, 685–690.
Ferlay, J., Shin, H.R., Bray, F., Forman, D., Mathers, C., & Parkin, D.M. (2010). Cancer incidence and mortality worldwide: IARC cancerBase no. 10. Retrieved from http://globocan.iarc.fr
Fife, C.E., Davey, S., Maus, E.A., Guiliod, R., & Mayrovitz, H.N. (2012). A randomized controlled trial comparing two types of pneumatic compression for breast cancer-related lymphedema treatment in the home. Supportive Care in Cancer, 20, 3279–3286. http://dx.doi.org/10.1007/s00520-012-1455-2
Fong, S.S., Ng, S.S., Luk, W.S., Chung, J.W., Ho, J.S., Ying, M., & Ma, A.W. (2014). Effects of qigong exercise on upper limb lymphedema and blood flow in survivors of breast cancer: A pilot study. Integrative Cancer Therapies, 13, 54–61.
Fu, M.R., Chen, C.M., Haber, J., Guth, A.A., & Axelrod, D. (2010). The effect of providing information about lymphedema on the cognitive and symptom outcomes of breast cancer survivors. Annals of Surgical Oncology, 17, 1847–1853.
Fu, M.R., & Rosedale, M. (2009). Breast cancer survivors’ experience of lymphedema related symptoms. Journal of Pain and Symptom Management, 38, 849–859.
Gautam, A.P., Maiya, A.G., & Vidyasagar, M.S. (2011). Effect of home-based exercise program on lymphedema and quality of life in female postmastectomy patients: Pre-post intervention study. Journal of Rehabilitation Research and Development, 48, 1261–1268. http://dx.doi.org/10.1682/JRRD.2010.05.0089
Gothard, L., Haviland, J., Bryson, P., Laden, G., Glover, M., Harrison, S., . . . Yarnold, J. (2010). Randomised phase II trial of hyperbaric oxygen therapy in patients with chronic arm lymphoedema after radiotherapy for cancer. Radiotherapy and Oncology, 97, 101–107. http://dx.doi.org/10.1016/j.radonc.2010.04.026
Guerreiro Godoy, M.D., Guimaraes, T.D., Oliani, A.H., & Pereira de Godoy, J.M. (2011). Association of Godoy and Godoy contention with mechanism with apparatus-assisted exercises in patients with arm lymphedema after breast cancer. International Journal of General Medicine, 4, 373–376. http://dx.doi.org/10.2147/IJGM.S17139
Guerreiro Godoy, M.F., Oliani, A.H., & Pereira de Godoy, J.M. (2010). Active exercises utilizing a facilitating device in the treatment of lymphedema resulting from breast cancer therapy. German Medical Science, 8, Doc31. http://dx.doi.org/10.3205/000120
Guerreiro Godoy, M.F., Pereira, M.R., Oliani, A.H., & Pereira de Godoy, J.M. (2012). Synergic effect of compression therapy and controlled active exercises using a facilitating device in the treatment of arm lymphedema. International Journal of Medical Sciences, 9, 280–284. http://dx.doi.org/10.7150/ijms.3272
Haghighat, S., Lofti-Tokaldany, M., Yunesian, M., Akbari, M.E., Nazemi, F., & Weiss, J. (2010). Comparing two treatment methods for post mastectomy lymphedema: Complex decongestive therapy alone and in combination with intermittent pneumatic compression. Lymphology, 43, 25–33.
Hayes, S.C., Reul-Hirche, H., & Turner, J. (2009). Exercise and secondary lymphedema: Safety, potential benefits, and research issues. Medicine and Science in Sports and Exercise, 41, 483–489.
Hwang, J.M., Hwang, J.H., Kim, T.W., Lee, S.Y., Chang, H.J., & Chu, I.H. (2013). Long-term effects of complex decongestive therapy in breast cancer patients with arm lymphedema after axillary dissection. Annals of Rehabilitation Medicine, 37, 690–697.
Hwang, K.H., Jeong, H.J., Kim, G.C., & Sim, Y.J. (2013). Clinical effectiveness of complex decongestive physiotherapy for malignant lymphedema: A pilot study. Annals of Rehabilitation Medicine, 37, 396–402. http://dx.doi.org/10.5535/arm.2013.37.3.396
Jeffs, E., & Wiseman, T. (2013). Randomized controlled trial to determine the benefit of daily home-based exercise in addition to self-care in the management of breast cancer-related lymphoedema: A feasibility study. Supportive Care in Cancer, 21, 1013–1023. http://dx.doi.org/10.1007/s00520-012-1621-6
Jemal, M., Bray, F., Center, M.M., Ferlay, J., Ward, E., & Forman, D. (2011). Global cancer statistics. CA: A Cancer Journal for Clinicians, 61, 69–90. http://dx.doi.org/10.3322/caac.20107
Johansson, K., Hayes, S., Speck, R.M., & Schmitz, K.H. (2013). Water-based exercise for patients with chronic arm lymphedema: A randomized controlled pilot trial. American Journal of Physical Medicine and Rehabilitation, 92, 312–319.
Johansson, K., Ohlsson, K., Ingvar, C., Albertsson, M., & Ekdahl, C. (2002). Factors associated with the development of arm lymphedema following breast cancer treatment: A match pair case-control study. Lymphology, 35, 59–71.
Johnson, L.A. (2014). Putting Evidence Into Practice: The process for evidence-based research. Clinical Journal of Oncology Nursing, 18(Suppl.), 5–7. http://dx.doi.org/10.1188/14.CJON.S3.5-7
Jonsson, C., & Johansson, K. (2009). Pole walking for patients with breast cancer–related arm lymphedema. Physiotherapy Theory and Practice, 25, 165–173. http://dx.doi.org/10.1080/09593980902776621
Kasseroller, R.G., & Brenner, E. (2010). A prospective randomised study of alginate-drenched low stretch bandages as an alternative to conventional lymphologic compression bandaging. Supportive Care in Cancer, 18, 343–350. http://dx.doi.org/10.1007/s00520-009-0658-7
Kim, D.S., Sim, Y.J., Jeong, H.J., & Kim, G.C. (2010). Effect of active resistive exercise on breast cancer–related lymphedema: A randomized controlled trial. Archives of Physical Medicine and Rehabilitation, 91, 1844–1848. http://dx.doi.org/10.1016/j.apmr.2010.09.008
King, M., Deveaux, A., White, H., & Rayson, D. (2012). Compression garments versus compression bandaging in decongestive lymphatic therapy for breast cancer-related lymphedema: A randomized controlled trial. Supportive Care in Cancer, 20, 1031–1036. http://dx.doi.org/10.1007/s00520-011-1178-9
Kozanoglu, E., Basaran, S., Paydas, S., & Sarpel, T. (2009). Efficacy of pneumatic compression and low-level laser therapy in the treatment of postmastectomy lymphoedema: A randomized controlled trial. Clinical Rehabilitation, 23, 117–124.
Kwan, M.L., Cohn, J.C., Armer, J.M., Stewart, B.R., & Cormier, J.N. (2011). Exercise in patients with lymphedema: A systematic review of the contemporary literature. Journal of Cancer Survivorship: Research and Practice, 5, 320–336.
Langer, I., Guller, U., Berclaz, G., Koechli, O.R., Schaer, G., Fehr, M.K., . . . Zuber, M. (2007). Morbidity of sentinel lymph node biopsy (SLN) alone versus SLN and completion axillary lymph node dissection after breast cancer surgery: A prospective Swiss multicenter study on 659 patients. Annals of Surgery, 245, 452–461. http://dx.doi.org/10.1097/01.sla.0000245472.47748.ec
Lasinski, B.B., Thrift, K.M., Squire, D., Austin, M.K., Smith, K.M., Wanchai, A., . . . Armer, J.M. (2012). A systematic review of the evidence for complete decongestive therapy in the treatment of lymphedema from 2004 to 2011. PM&R, 4, 580–601.
Leal, N.F., Carrara, H.H., Vieira, K.F., & Ferreira, C.H. (2009). Physiotherapy treatments for breast cancer-related lymphedema: A literature review. Revista Latino-Americana de Enfermagem, 17, 730–736.
Liao, S.F., Li, S.H., Huang, H.Y., Chen, S.T., Kuo, S.J., Chen, D.R., & Wei, T.S. (2013). The efficacy of complex decongestive physiotherapy (CDP) and predictive factors of lymphedema severity and response to CDP in breast cancer–related lymphedema (BCRL). Breast, 22, 703–706. http://dx.doi.org/10.1016/j.breast.2012.12.018
Maher, J., Refshauge, K., Ward, L., Paterson, R., & Kilbreath, S. (2012). Change in extracellular fluid and arm volumes as a consequence of a single session of lymphatic massage followed by rest with or without compression. Supportive Care in Cancer, 20, 3079–3086. http://dx.doi.org/10.1007/s00520-012-1433-8
Maldonado, G.E., Perez, C.A., Covarrubias, E.E., Cabriales, S.A., Leyva, L.A., Perez, J.C., & Almaguer, D.G. (2011). Autologous stem cells for the treatment of post-mastectomy lymphedema: A pilot study. Cytotherapy, 13, 1249–1255.
Malicka, I., Stefanska, M., Rudziak, M., Jarmoluk, P., Pawłowska, K., Szczepanska-Gieracha, J., & Wozniewski, M. (2011). The influence of Nordic walking exercise on upper extremity strength and the volume of lymphoedema in women following breast cancer treatment. Isokinetics and Exercise Science, 19, 295–304. http://dx.doi.org/10.3233/IES-2011-0430
Martin, M.L., Hernandez, M.A., Avendano, C., Rodrigues, F., & Martinez, H. (2011). Manual lymphatic drainage therapy in patients with breast cancer related lymphoedema. BMC Cancer, 11, 94.
McClure, M.K., McClure, R.J., Day, R., & Brufsky, A.M. (2010). Randomized controlled trial of the Breast Cancer Recovery Program for women with breast cancer-related lymphedema. American Journal of Occupational Therapy, 64, 59–72.
McLaughlin, S.A., Bagaria, S., Gibson, T., Arnold, M., Diehl, N., Crook, J., . . . Nguyen, J. (2013). Trends in risk reduction practices for the prevention of lymphedema in the first 12 months after breast cancer surgery. Journal of the American College of Surgeons, 216, 380–389. http://dx.doi.org/10.1016/j.jamcollsurg.2012.11.004
McLaughlin, S.A., Wright, M.J., Morris, K.T., Giron, G.L., Sampson, M.R., Brockway, J.P., . . . Van Zee, K.J. (2008). Prevalence of lymphedema in women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection: Objective measurements. Journal of Clinical Oncology, 26, 5213–5219.
McNeely, M.L., Campbell, K., Ospina, M., Rowe, B.H., Dabbs, K., Klassen, T.P., . . . Courneya, K. (2010). Exercise interventions for upper-limb dysfunction due to breast cancer treatment. Cochrane Database of Systematic Reviews, 6, CD005211. http://dx.doi.org/10.1002/14651858.CD005211.pub2
McNeely, M.L., Peddle, C.J., Yurick, J.L., Dayes, I.S., & Mackey, J.R. (2011). Conservative and dietary interventions for cancer-related lymphedema: A systematic review and meta-analysis. Cancer, 117, 1136–1148. http://dx.doi.org/10.1002/cncr.25513
Mitchell, S.A., & Friese, C.R. (n.d.). ONS PEP (Putting Evidence Into Practice) weight of evidence classification schema. Decision rules for summative evaluation of a body of evidence. Retrieved from http://www2.ons.org/Research/media/ons/docs/research/outcomes/weight-of-evidence-table.pdf
Moattari, M., Jaafari, B., Talei, A., Piroozi, S., Tahmasebi, S., & Zakeri, Z. (2012). The effect of combined decongestive therapy and pneumatic compression pump on lymphedema indicators in patients with breast cancer–related lymphedema. Iranian Red Crescent Medical Journal, 14, 210–217.
Paskett, E.D., Naughton, M.J., McCoy, T.P., Case, L.D., & Abbott, J.M. (2007). The epidemiology of arm and hand swelling in premenopausal breast cancer survivors. Cancer Epidemiology, Biomarkers and Prevention, 16, 775–782.
Petrek, J.A., Senie, R.T., Peters, M., & Rosen, P.P. (2001). Lymphedema in a cohort of breast carcinoma survivors 20 years after diagnosis. Cancer, 92, 1368–1377.
Poage, E., Singer, M., Armer, J.M., Poundall, M., & Shellabarger, J. (2008). Demystifying lymphedema: Development of the lymphedema Putting Evidence Into Practice card. Clinical Journal of Oncology Nursing, 12, 951–964. http://dx.doi.org/10.1188/08.CJON.951-964
Randheer, S., Kadambari, D., Srinivasan, K., Bhuvaneswari, V., Bhanumathy, M., & Salaja, R. (2011). Comprehensive decongestive therapy in postmastectomy lymphedema: An Indian perspective. Indian Journal of Cancer, 48, 397–402.
Ridner, S.H., Fu, M.R., Wanchai, A., Stewart, B.R., Armer, J.M., & Cormier, J.N. (2012). Self-management of lymphedema: A systematic review of the literature from 2004 to 2011. Nursing Research, 61, 291–299. http://dx.doi.org/10.1097/NNR.0b013e31824f82b2
Ridner, S.H., Murphy, B., Deng, J., Kidd, N., Galford, E., Bonner, C., . . . Dietrich, M.S. (2012). A randomized clinical trial comparing advanced pneumatic truncal, chest, and arm treatment to arm treatment only in self-care of arm lymphedema. Breast Cancer Research and Treatment, 131, 147–158. http://dx.doi.org/10.1007/s10549-011-1795-5
Rodrick, J.R., Poage, E., Wanchai, A., Stewart, B.R., Cormier, J.N., & Armer, J.M. (2014). Complementary, alternative, and other non-complete decongestive therapy (CDT) treatment methods in the management of lymphedema: A systematic search and review. PM&R, 6, 250–274. http://dx.doi.org/10.1016/j.pmrj.2013.09.008
Sagen, A., Karesen, R., & Risberg, M.A. (2009). Physical activity for the affected limb and arm lymphedema after breast cancer surgery. A prospective, randomized controlled trial with two years follow-up. Acta Oncologica, 48, 1102–1110.
Sawan, S., Mugnai, R., Lopes Ade, B., Hughes, A., & Edmondson, R.J. (2009). Lower-limb lymphedema and vulval cancer: Feasibility of prophylactic compression garments and validation of leg volume measurement. International Journal of Gynecological Cancer, 19, 1649–1654. http://dx.doi.org/10.1111/IGC.0b013e3181a8446a
Scaffidi, M., Vulpiani, M.C., Vetrano, M., Conforti, F., Marchetti, M.R., Bonifacino, A., . . . Ferretti, A. (2012). Early rehabilitation reduces the onset of complications in the upper limb following breast cancer surgery. European Journal of Physical and Rehabilitation Medicine, 48, 601–611.
Schaverien, M.V., Munro, K.J., Baker, P.A., & Munnoch, D.A. (2012). Liposuction for chronic lymphoedema of the upper limb: 5 years of experience. Journal of Plastic, Reconstructive and Aesthetic Surgery, 65, 935–942. http://dx.doi.org/10.1016/j.bjps.2012.01.021
Schmitz, K.H., Ahmed, R.L., Troxel, A.B., Cheville, A., Lewis-Grant, L., Smith, R., . . . Chittams, J. (2010). Weight lifting for women at risk for breast cancer–related lymphedema: A randomized trial. JAMA, 304, 2699–2705. http://dx.doi.org/10.1001/jama.2010.1837
Shih, Y.C., Xu, Y., Cormier, J.N., Giordano, S., Ridner, S.H., Buchholz, T.A., . . . Elting, L.S. (2009). Incidence, treatment costs, and complications of lymphedema after breast cancer among women of working age: A 2-year follow-up study. Journal of Clinical Oncology, 27, 2007–2014. http://dx.doi.org/10.1200/JCO.2008.18.3517
Stanton, A.W., Modi, S., Mellor, R.H., Levick, J.R., & Mortimer, P.S. (2009). Recent advances in breast cancer-related lymphedema of the arm: Lymphatic pump failure and predisposing factors. Lymphatic Research and Biology, 7, 29–45.
Tidhar, D., & Katz-Leurer, M. (2010). Aqua lymphatic therapy in women who suffer from breast cancer treatment–related lymphedema: A randomized controlled study. Supportive Care in Cancer, 18, 383–392. http://dx.doi.org/10.1007/s00520-009-0669-4
Torress Lacomba, M., Yuste Sánchez, M.J., Zapico Goñi, Á., Prieto Merino, D., Mayoral del Moral, O., Cerezo Téllez, E., & Minayo Mogollón, E. (2010). Effectiveness of early physiotherapy to prevent lymphoedema after surgery for breast cancer: Randomised, single blinded, clinical trial. BMJ, 340, b5396.
Tsai, H.J., Hung, H.C., Yang, J.L., Huang, C.S., & Tsauo, J.Y. (2009). Could Kinesio tape replace the bandage in decongestive lymphatic therapy for breast-cancer–related lymphedema? A pilot study. Supportive Care in Cancer, 17, 1353–1360.
Vignes, S., Blanchard, M., Arrault, M., & Porcher, R. (2013). Intensive complete decongestive physiotherapy for cancer-related upper-limb lymphedema: 11 days achieved greater volume reduction than 4. Gynecologic Oncology, 131, 127–130.
Vignes, S., Porcher, R., Arrault, M., & Dupuy, A. (2011). Factors influencing breast cancer–related lymphedema volume after intensive decongestive physiotherapy. Supportive Care in Cancer, 19, 935–940. http://dx.doi.org/10.1007/s00520-010-0906-x
Woo, J.H., Park, H.S., Kim, S.C., & Kim, Y.H. (2013). The effect of lumbar sympathetic ganglion block on gynecologic cancer-related lymphedema. Pain Physician, 16, 345–352.
Zimmermann, A., Wozniewski, M., Szklarska, A., Lipowicz, A., & Szuba, A. (2012). Efficacy of manual lymphatic drainage in preventing secondary lymphedema after breast cancer surgery. Lymphology, 45, 103–112.
Mei R. Fu, PhD, RN, ACNS-BC, FAAN, is an associate professor in the College of Nursing at New York University in New York; Jie Deng, PhD, RN, OCN®, is an assistant professor in the School of Nursing at Vanderbilt University in Nashville, TN; and Jane M. Armer, PhD, RN, FAAN, is a professor in the School of Nursing at the University of Missouri in Columbia. The authors take full responsibility for the content of the article. The authors did not receive honoraria for this work. The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. No financial relationships relevant to the content of this article have been disclosed by the authors, planners, independent peer reviewers, or editorial staff. Fu can be reached at firstname.lastname@example.org, with copy to editor at CJONEditor@ons.org. (Submitted April 2014. Revision submitted July 2014. Accepted for publication August 2, 2014.)
Key words: lymphedema; cancer; therapy; compression; bandaging; information