Imagery and metaphors are used throughout health communication and can be particularly powerful in discourse about cancer. Providers, patients, and the media may use descriptive language to convey the impact and experience of the disease. This article reviews the literature on metaphor in discourse about cancer and its effects. Also, the positive and negative effects of popular cancer-related imagery, such as military and journey metaphors, are explored. Metaphor can be used in nursing, through thoughtful use of imagery, to improve patient-centered care. By noting the imagery used by patients to describe their experiences with cancer, nurses can find a common language for connecting with patients and can advocate for greater awareness and more sensitive communication by other healthcare providers.