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Advanced Practice Nursing Issues
Epstein-Barr Virus Infection and Lymphoproliferative Disorder After Hematopoietic Cell Transplantation
CJON 2012, 16(2), 211-214 DOI: 10.1188/12.CJON.211-214
Common herpes viruses such as Epstein-Barr virus (EBV) cause infection and disease after hematopoietic cell transplantation (HCT). Post-transplantation lymphoproliferative disorder following allogeneic HCT is a rare but life-threatening disease, mostly associated with EBV-infected B cells. Anti-CD20 monoclonal antibodies (e.g., rituximab) target normal and infected B cells and further suppress the patient's immune system. This article describes the development of cellular therapies by infusing virus-specific cytotoxic T lymphocytes via IV into patients to create an adoptive immune system for specific viral suppression.
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