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Advanced Practice Nursing Issues

Management of Chronic Graft-Versus-Host Disease

Melissa Baker
Phyllis McKiernan
CJON 2011, 15(4), 429-432 DOI: 10.1188/11.CJON.429-432

Chronic graft-versus-host disease (GVHD) is an immune-mediated disorder that adversely affects quality of life and clinical outcomes in patients following hematopoietic stem cell transplantation. Conventional treatment of GVHD includes prolonged and high-dose corticosteroids; however, those drugs are associated with multiple side effects. This article describes the ability of extracorporeal photopheresis therapy to exhibit a steroid-sparing effect, which can reduce long-term complications as a consequence of steroid treatment.

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