No votes yet

Severe Fatigue: Could It Be Aplastic Anemia?

Manuel G. Afable
Debra E. Lyon
CJON 2008, 12(4), 569-573 DOI: 10.1188/08.CJON.569-573

Bacigalupo, A., Brand, R., Oneto, R., Bruno, B., Socie, G., Passweg, J., et al. (2000). Treatment of acquired severe aplastic anemia: Bone marrow transplantation compared with immunosuppressive therapy—The European Group for Blood and Marrow Transplantation experience. <i>Seminars in Hematology</i>, <b>37</b>(1), 69-80.

Frickhofen, N., Heimpel, H., Kaltwasser, J. P., & Schrezenmeier, H. (2003). Antithymocyte globulin with or without cyclosporine A: 11 year follow-up of a randomized trial comparing treatments of aplastic anemia. <i>Blood</i>, <b>101</b>(4), 1236-1242.

Kojima, S., Hibi, S., Kosaka, Y., Yamamoto, M., Tsuchida, M., Mugushima, H., et al. (2000). Immunosuppressive therapy using antithymocyte globulin, syclosporine, and danazol with or without human granulocyte-colony-stimulating factor in children with acquired aplastic anemia. <i>Blood</i>, <b>96</b>(6), 2049-2054.

Maciejewski, J. P., & Risitano, A. M. (2005). Aplastic anemia: Management of adult patients. <i>American Society of Hematology Education Program</i>, <b>1</b>, 110-117.

Maciejewski, J. P., Selleri, C., Anderson, S., & Young, N. S. (1995). Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro. <i>Blood</i>, <b>85</b>(11), 3183-3190.

Marsh, J. C., Ball, S. E., Darbyshire, P., Gordon-Smith, E. C., Keidan, A. J., Martin, A., et al. (2003). Guidelines for the diagnosis and management of acquired aplastic anemia. <i>British Journal of Haematology</i>, <b>123</b>(5), 782-801.

Mathe, G., Amiel, J. L., Schwarzenberg, L., Choay, J., Trolard, P., Schneider, M., et al. (1970). Bone marrow graft in man after conditioning by antilymphocytic serum. <i>BMJ</i>, <b>2</b>(5702), 131-136.

Mueller, T. F. (2007). Mechanisms of actions of thymoglobulin. <i>Transplantation</i>, <b>84</b>(11, Suppl.), S5-S10.

Rosenfeld, S., Follmann, D., Nunez, O., & Young, N. S. (2003). Antithymocyte globulin and cyclosporine for severe aplastic anemia: Association between hematologic response and long-term outcome. <i>Journal of the American Medical Association</i>, <b>289</b>(9), 1130-1135.

Scheinberg, P., Nunez, O., Wu, C., & Young, N. S. (2006). Treatment of severe aplastic anemia with combined immunosupression: Antithymocyte globulin, cyclosporin, and mycophenolate mofetil. <i>British Journal of Haematology</i>, <b>133</b>(6), 606-611.

Schrier, S. L. (2007). Aplastic anemia: Pathogenesis; clinical manifestations; and diagnosis. Retrieved May 8, 2008, from <a target="_blank" href='http://www.uptodateonline.com'>http://www.uptodateonline.com</a>

Schrier, S. L. (2008). Aplastic anemia: Prognosis and treatment. Retrieved January 25, 2008, from <a target="_blank" href='http://www.uptodateonline.com'>http://www.uptodateonline.com</a>

Sloand, E. M., Kim, S., Maciejewski, J. P., Tisdale, J., Follmann, D., & Young, N. S. (2002). Intracellular interferon-gamma in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia. <i>Blood</i>, <b>100</b>(4), 1185-1191.

Solomou, E. E., Keyvanfar, K., & Young, N. S. (2006). T-bet, a Th1 transcription factor, is upregulated in T cells from patients with aplastic anemia. <i>Blood</i>, <b>107</b>(10), 3983-3991.

Tichelli, A., Socie, G., Henry-Amar, M., Marsh, J., Passweg, J., Schrezenmeier, H., et al. (1999). Effectiveness of immunosuppressive therapy in older patients with aplastic anemia: A report from the European Blood and Marrow Transplant (EBMT) Severe Aplastic Anemia Working Party. <i>Annals of Internal Medicine</i>, <b>130</b>(3), 193-201.

Young, N. S. (1995). Aplastic anemia. <i>Lancet</i>, <b>346</b>(8969), 228-232.

Young, N. S., Calado, R. T., & Scheinberg, P. (2006). Current concepts in the pathopysiology and treatment of aplastic anemia. <i>Blood</i>, <b>108</b>(8), 2509-2519.

Young, N. S., & Maciejewski, J. (1997). The pathophysiology of acquired aplastic anemia. <i>New England Journal of Medicine</i>, <b>336</b>(19), 1365-1372.

Young, N. S., Scheinberg, P., & Calado, R. T. (2008). Aplastic anemia. <i>Current Opinion in Hematology</i>, <b>15</b>(3), 162-168.

Gluckman, E., Rokicka-Milewska, R., Hann, I., Nikiforakis, E., Tavakoli, F., Cohen-Scali, S., et al. (2002). Results and follow-up of a phase III randomized study of recombinant human-granulocyte stimulating factor as support for immunosuppressive therapy in patients with severe aplastic anaemia. <i>British Journal of Haematology</i>, <b>119</b>(4), 1075-1082.

Horowitz, M. M. (2000). Current status of allogeneic bone marrow transplantation in acquired aplastic anemia. <i>Seminars in Hematology</i>, <b>37</b>(1), 30-42.

Issaragrisil, S., Kaufman, D. W., Anderson, T., Chansung, K., Leaverton, P. E., Shapiro, S., et al. (2006). The epidemiology of aplastic anemia in Thailand. <i>Blood</i>, <b>107</b>(4), 1299-1307.

Bacigalupo, A. (2007). Aplastic anemia: Pathogenesis and treatment. <i>American Society of Hematology Education Program</i>, <b>1</b>, 23-28.