0
No votes yet
Evidence-Based Practice
Open Access Article

Putting Evidence Into Practice®: Evidence-Based Interventions for Chemotherapy-Induced Peripheral Neuropathy

Constance Visovsky
Mary Collins
Linda Abbott
Julie Aschenbrenner
Connie Hart
CJON 2007, 11(6), 901-913 DOI: 10.1188/07.CJON.901-913

Chemotherapy-induced peripheral neuropathy (CIPN) continues to be a significant, debilitating symptom resulting from the administration of neurotoxic chemotherapy for the treatment of cancer. CIPN is an important consequence of cancer treatment because of its potential impact on physical functioning and quality of life. Oncology nurses play an important role in assessing, monitoring, and educating clients about CIPN. Despite investigations concerning pharmacologic and nonpharmacologic approaches to either preventing or minimizing the neurotoxicity resulting from certain chemotherapeutic agents, evidence to support the interventions is lacking. This article presents information concerning CIPN and summarizes the evidence for pharmacologic and nonpharmacologic approaches to the prevention and treatment of CIPN.

References 

Abuaisha, B.B., Costanzi, J.B., & Boulton, A.J. (1998). Acupuncture for the treatment of chronic painful peripheral diabetic neuropathy: A long-term study. <i>Diabetes Research and Clinical Practice</i>, 39, 115-121.

Almadrones, L., & Arcot, R. (1999). Patient guide to peripheral neuropathy. <i>Oncology Nursing Forum</i>, 26, 1359-1360.

Argyriou, A.A., Chroni, E., Koutras, A., Ellul, J., Papapetropoulos, S., Katsoulas, G., et al. (2005). Vitamin E for prophylaxis against chemotherapy-induced neuropathy: A randomized controlled trial. <i>Neurology</i>, 64, 26-31.

Armstrong, T., Almadrones, L., & Gilbert, M. (2005). Chemotherapyinduced peripheral neuropathy. <i>Oncology Nursing Forum</i>, 32, 305-311.

Arnall, D.A., Nelson, A.G., Lopez, L., Sanz, N., Iversen, L., Sanz, I., et al. (2006). The restorative effects of pulsed infrared light therapy on significant loss of peripheral protective sensation in patients with long-term type 1 and type 2 diabetes mellitus. <i>Acta Diabetologica</i>, 43, 26-33.

Ashton-Miller, J., Yeh, M., Richardson, J.K., & Galloway, T. (1996). A cane reduces loss of balance in patients with peripheral neuropathy: Results from a challenging unipedal balance test. <i>Archives of Physical Medicine and Rehabilitation</i>, 77, 446-452.

Balducci, S., Iacobellis, G., Parisi, L., Di Biase, N., Calandriello, E., Leonetti, F., et al. (2006). Exercise training can modify the natural history of diabetic peripheral neuropathy. <i>Journal of Diabetes and Its Complications</i>, 20, 216-223.

Bianchi, G., Vitali, G., Caraceni, A., Ravaglia, S., Capri, G., Cundari, S., et al. (2005). Symptomatic and neurophysiological responses of paclitaxel- or cisplatin-induced neuropathy to oral acetyl-L-carnitine. <i>European Journal of Cancer</i>, 41, 1746-1750.

Bove, L., Picardo, M., Maresca, V., Jandolo, B., & Pace, A. (2001). A pilot study on the relation between cisplatin neuropathy and vitamin E. <i>Journal of Experimental and Clinical Cancer Research</i>, 20, 277-280.

Cascinu, S., Catalano, V., Cordella, L., Labianca, R., Giordani, P., Baldelli, A.M., et al. (2002). Neuroprotective effect of reduced glutathione on oxaliplatin-based chemotherapy in advanced colorectal cancer: A randomized, double-blind, placebo-controlled trial. <i>Journal of Clinical Oncology</i>, 20, 3478-3483.

Cascinu, S., Cordella, L., Del Ferro, E., Fronzoni, M., & Catalano, G. (1995). Neuroprotective effect of reduced glutathione on cisplatin-based chemotherapy in advanced gastric cancer: A randomized double-blind placebo-controlled trial. <i>Journal of Clinical Oncology</i>, 13, 26-32.

Cata, J.P., Cordella, J.V., Burton, A.W., Hassenbusch, S.J., Weng, H.R., & Dougherty, P.M. (2004). Spinal cord stimulation relieves chemotherapy-induced pain: A clinical case report. <i>Journal of Pain and Symptom Management</i>, 27, 72-78.

Cavaletti, G., & Zanna, C. (2002). Current status and future prospects for the treatment of chemotherapy-induced peripheral neurotoxicity. <i>European Journal of Cancer</i>, 38, 1832-1837.

Davis, I.D., Kiers, L., MacGregor, L., Quinn, M., Arezzo, J., Green, M., et al. (2005). A randomized, double-blinded, placebo-controlled phase II trial of recombinant human leukemia inhibitory factor (rhuLIF, emfilermin, AM424) to prevent chemotherapy-induced peripheral neuropathy. <i>Clinical Cancer Research</i>, 11, 1890-1898.

Eckel, F., Schmelz, R., Adelsberger, H., Erdmann, J., Quasthoff, S., & Lersch, C. (2002). [Prevention of oxaliplatin-induced neuropathy by carbamazepine. A pilot study.] <i>Deutsche Medizinische Wochenschrift</i>, 127, 78-82.

Forst, T., Nguyen, M., Forst, S., Disselhoff, B., Pohlmann, T., & Pfutzner, A. (2004). Impact of low frequency transcutaneous electrical nerve stimulation on symptomatic diabetic neuropathy using the new Salutaris device. <i>Diabetes, Nutrition and Metabolism</i>, 17, 163-168.

Forst, T., Pohlmann, T., Kunt, T., Goitom, K., Schulz, G., Lobig, M., et al. (2002). The influence of local capsaicin treatment on small nerve fibre function and neurovascular control in symptomatic diabetic neuropathy. <i>Acta Diabetologica</i>, 39, 1-6.

Gamelin, L., Boisdron-Celle, M., Delva, R., Geurin-Meyer, V., Ifrah, N., Morel, A., et al. (2004). Prevention of oxaliplatin-related neurotoxicity by calcium and magnesium infusions: A retrospective study of 161 patients receiving oxaliplatin combined with 5-fluorouracil and leucovorin for advanced colorectal cancer. <i>Clinical Cancer Research</i>, 10, 4055-4061.

Given, B., & Sherwood, P. (2005). Nursing sensitive patient outcomes—A white paper. <i>Oncology Nursing Forum</i>, 32, 773-784.

Hammack, J., Michalak, J., Loprinzi, C., Sloan, J., Novotny, P., Soori, G., et al. (2002). Phase III evaluation of nortriptyline for alleviation of symptoms of cisplatinum-induced peripheral neuropathy. <i>Pain</i>, 98, 195-203.

Hilpert, F., Stahle, A., Tome, O., Burges, A., Rossner, D., Spathe, K., et al. (2005). Neuroprotection with amifostine in the first-line treatment of advanced ovarian cancer with carboplatin/paclitaxel-based chemotherapy. A double blind, placebo-controlled, randomized phase II study from the Arbeitsgemeinschaft Gynakologische Onkologoie (AGO) Ovarian Cancer Study Group. <i>Supportive Care in Cancer</i>, 13, 797-805.

Jiang, H., Shi, K., Li, X., Zhou, W., & Cao, Y. (2006). Clinical study on the wrist-ankle acupuncture treatment for 30 cases of diabetic peripheral neuritis. <i>Journal of Traditional Chinese Medicine</i>, 26, 8-12.

Leonard, D.R., Farooqi, M.H., & Myers, S. (2004). Restoration of sensation, reduced pain, and improved balance in subjects with diabetic peripheral neuropathy: A double-blind, randomized, placebo-controlled study with monochromatic near-infrared treatment. <i>Diabetes Care</i>, 27, 168-172.

Lindeman, E., Leffers, P., Spaans, F., Drukker, J., Reulen, J., Kerckhoffs, M., et al. (1995). Strength training in patients with myotonic dystrophy and hereditary motor and sensory neuropathy: A randomized clinical trial. <i>Archives of Physical Medicine and Rehabilitation</i>, 76, 612-620.

Maestri, A., De Pasquale Ceratti, A., Cundari, S., Zanna, C., Cortesi, E., & Crino, L. (2005). A pilot study on the effect of acetyl-L-carnitine in paclitaxel- and cisplatin-induced peripheral neuropathy. <i>Tumori</i>, 91, 135-138.

Marrs, J., & Newton, S. (2003). Updating your peripheral neuropathy "know how." <i>Clinical Journal of Oncology Nursing</i>, 7, 299-303.

Mitchell, S.A., & Friese, C.R. (n.d.). Weight of evidence. Retrieved October 19, 2006, from <a target="_blank" href='http://www.ons.org/outcomes/tables/sleep/woe.shtml'>http://www.ons.org/o...

Moore, D., Donnelly, J., McGuire, W.P., Almadrones, L., Cella, D.F., Herzog, T.J., et al. (2003). Limited access trial using amifostine for protection against cisplatin and three hour paclitaxel-induced neurotoxicity: A phase II study of the Gynecologic Oncology Group. <i>Journal of Clinical Oncology</i>, 21, 4207-4213.

Ocean, A.J., & Vahdat, L.T. (2004). Chemotherapy-induced peripheral neuropathy: Pathogenesis and emerging therapies. <i>Supportive Care in Cancer</i>, 12, 619-625.

Openshaw, H., Beamon, K., Synod, T.W., Longmate, J., Slatkin, N.E., Doroshaw, J.H., et al. (2004). Neurophysiolgical study of peripheral neuropathy after high-dose paclitaxel: Lack of neuroprotective effect of amifostine. <i>Clinical Cancer Research</i>, 10, 461-467.

Pace, A., Savarese, A., Picardo, M., Maresca, V., Pacetti, U., Del Monte, G., et al. (2003). Neuroprotective effect of vitamin E supplementation in patients treated with cisplatin chemotherapy. <i>Journal of Clinical Oncology</i>, 21, 927-931.

Paice, J.A. (2007). Peripheral neuropathy: Experimental findings, clinical approaches. <i>Supportive Oncology</i>, 5(2), 61-63.

Phillips, K.D., Skelton, W.D., & Hand, G.A. (2004). Effect of acupuncture administered in a group setting on pain and subjective peripheral neuropathy in persons with human immunodeficiency virus disease. <i>Journal of Alternative and Complementary Medicine</i>, 10, 449-455.

Postma, T.J., & Heimans, J.J. (2000). Grading of chemotherapyinduced peripheral neuropathy. <i>Annals of Oncology</i>, 11, 509-513.

Prendergast, J.J., Miranda, G., & Sanchez, M. (2004). Improvement of sensory impairment in patients with peripheral neuropathy. <i>Endocrine Practice</i>, 10, 24-30.

Reichstein, L., Labrenz, S., Ziegler, D., & Martin, S. (2005). Effective treatment of symptomatic diabetic polyneuropathy by high-frequency external muscle stimulation. <i>Diabetologia</i>, 48, 824-828.

Richardson, J.K., Sandman, D., & Vela, S. (2001). A focused exercise regimen improves clinical measures of balance in patients with peripheral neuropathy. <i>Archives of Physical Medicine and Rehabilitation</i>, 82, 205-209.

Richardson, J.K., Thies, S., DeMott, T., & Ashton-Miller, J.A. (2004). Interventions improve gait regularity in patients with peripheral neuropathy while walking on an irregular surface under low light. <i>Journal of the American Geriatrics Society</i>, 52, 510-515.

Shlay, J.C., Chaloner, K., Max, M.B., Flaws, B., Reichelderfer, P., Wentworth, D., et al. (1998). Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: A randomized controlled trial. <i>JAMA</i>, 280, 1590-1595.

Smyth, J.F., Bowman, A., Perren, T., Wilkinson, P., Prescott, R.J., Quinn, K.J., et al. (1997). Glutathione reduces the toxicity and improves quality of life of women diagnosed with ovarian cancer treated with cisplatin: Results of a double-blind, randomized trial. <i>Annals of Oncology</i>, 8, 569-573.

Stubblefield, M.D., Vahdat, L.T., Balmaceda, A.B., Troxel, A.B., Hesdorffer, C.S., & Gooch, C.L. (2005). Glutamine as a neuroprotective agent in high-dose paclitaxel-induced peripheral neuropathy: A clinical and electrophysiologic study. <i>Clinical Oncology</i>, 17, 271-276.

Vahdat, L., Papadopoulos, K., Lange, D., Leuin, S., Kaufman, E., Donovan, D., et al. (2001). Reduction of paclitaxel-induced peripheral neuropathy with glutamine. <i>Clinical Cancer Research</i>, 7, 1192-1197.

Weijl, N.I., Hopman, G.D., Wipkink-Bakker, A., Lentjes, E.G., Berger, H.M., Cleton F.J., et al. (1998). Cisplatin combination chemotherapy induces a fall in plasma antioxidants of cancer patients. <i>Annals of Oncology</i>, 9, 1331-1337.

White, C.M., Pritchard, J., & Turner-Stokes, L. (2004). Exercise for people with peripheral neuropathy. <i>Cochrane Database of Systematic Reviews</i> 2004, Issue 4. Art. No.: CD003904. DOI: 10.1002/14651858.CD003904.pub2.

Wong, R., & Sagar, S. (2006). Acupuncture treatment for chemotherapy-induced peripheral neuropathy—A case series. <i>Acupuncture in Medicine</i>, 24(2), 87-91.

Ziegler, D., Nowak, H., Kempler, P., Vargha, P., & Low, P.A. (2004). Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. <i>Diabetic Medicine</i>, 21, 114-121.

Ashton-Miller, J., Yeh, M., Richardson, J.K., & Galloway, T. (1996). A cane reduces loss of balance in patients with peripheral neuropathy: Results from a challenging unipedal balance test. <i>Archives of Physical Medicine and Rehabilitation</i>, 77, 446-452.

Richardson, J.K., Thies, S., DeMott, T., & Ashton-Miller, J.A. (2004). Interventions improve gait regularity in patients with peripheral neuropathy while walking on an irregular surface under low light. <i>Journal of the American Geriatrics Society</i>, 52, 510-515.

Maestri, A., De Pasquale Ceratti, A., Cundari, S., Zanna, C., Cortesi, E., & Crino, L. (2005). A pilot study on the effect of acetyl-L-carnitine in paclitaxel- and cisplatin-induced peripheral neuropathy. <i>Tumori</i>, 91, 135-138.

Bianchi, G., Vitali, A., Ravaglia, S., Capri, G., Cundari, S., Zanna, C., et al. (2005). Symptomatic and neurophysiological responses of paclitaxel or cisplatin induced neuropathy to oral acetyl-L-carnitine. <i>European Journal of Cancer</i>, 41, 1746-1750.

Ziegler, D., Nowak, H., Kempler, P., Vargha, P., & Low, P.A. (2004). Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. <i>Diabetic Medicine</i>, 21, 114-121.

Hilpert, F., Stahle, A., Tome, O., Burges, A., Rossner, D., Spatke, K., et al. (2005). Neuroprotection with amifostine in the first-line treatment of advanced ovarian cancer with carboplatin/paclitaxel-based chemotherapy. A double blind, placebo-controlled, randomized phase II study from the Arbeitsgemein Schaft Gynaklogiscke Onkologie (AGO) Ovarian Cancer Study Group. <i>Supportive Care in Cancer</i>, 13, 797-805.

Moore, D., Donnelly, J., McGuire, W.P., Almadrones, L., Cella, D.F., Herzog, T.J., et al. (2003). Limited access trial using amifostine for protection against cisplatin and three hour paclitaxel-induced neurotoxicity: A phase II study of the Gynecologic Oncology Group. <i>Journal of Clinical Oncology</i>, 21, 4207-4213.

Openshaw, H., Beamon, K., Synold, T.W., Lougmate, J., Slatkin, N.E., Doroshaw, J.H., et al. (2004). Neuropshysiological study of peripheral neuropathy after high-dose paclitaxel: Lack of neuroprotective effect of amifostine. <i>Clinical Cancer Research</i>, 10, 461-467.

Gamelin, L., Boisdron-Celle, M., Delva, R., Geurin-Meyer, V., Ifrah, N., Morel, A., et al. (2004). Prevention of oxaliplatin-related neurotoxicity by calcium and magnesium infusions: A retrospective study of 161 patients receiving oxaliplatin combined with 5-fluorouracil and leucovorin for advanced colorectal cancer. <i>Clinical Cancer Research</i>, 10, 4055-4061.

Eckel, F., Schmelz, R., Adelsberger, H., Erdmann, J., Quasthoff, F., & Lersch, C. (2002). [Prevention of oxaliplatin-induced neuropathy by carbamazepine. A pilot study.] <i>Deutsche Medizinische Wochenschrift</i>, 127, 78-82.

Stubblefield, M.D., Vahdat, L.T., Balmaceda, C.M., Troxel, A.B., Hesdorffer, C.S., & Gooch, C.L. (2005). Glutamine as a neuroprotective agent in high-dose paclitaxel-induced peripheral neuropathy: A clinical and electrophysiologic study. <i>Clinical Oncology</i>, 17, 271-276.

Vahdat, L., Papadopoulos, K., Lange, D., Leuin, S., Kaufman, E., Donovan, D., et al. (2001). Reduction of paclitaxel-induced peripheral neuropathy with glutamine. <i>Clinical Cancer Research</i>, 7, 1192-1197.

Cascinu, S., Catalano, V., Cordella, L., Labiance, R., Giordani, P., Baldelli, A.M., et al. (2002). Neuroprotective effect of reduced glutathione on oxaliplatinbased chemotherapy in advanced colorectal cancer: A randomized, doubleblind, placebo-controlled trial. <i>Journal of Clinical Oncology</i>, 20, 3478-3483.

Smyth, J.F., Bowman, A., Perren, T., Wilkinson, P., Prescott, R.J., Quinn, K.J., et al. (1997). Glutathione reduces the toxicity and improves quality of life of women diagnosed with ovarian cancer treated with cisplatin: Results of a double-blind, randomized trial. <i>Annals of Oncology</i>, 8, 569-573.

Cascinu, S., Cordella, L., Del Ferro, E., Fronzoni, M., & Catalana, G. (1995). Neuroprotective effect of reduced glutathione on cisplatin-based chemotherapy in advanced gastric cancer: A randomized double-blind placebo-controlled trial. <i>Journal of Clinical Oncology</i>, 13, 26-32.

Hammack, J., Michalak, J., Loprinzi, C., Sloan, J., Novotny, P., Soori, G., et al. (2002). Phase III evaluation of nortriptyline for alleviation of symptoms of cisplatinum-induced peripheral neuropathy. <i>Pain</i>, 98, 195-203.

Davis, I.D., Kiers, L., MacGregor, L., Quinn, M., Arezo, J., Green, M., et al. (2005). A randomized, double-blinded, placebo-controlled phase II trial of recombinant human leukemia inhibitory factor (rhuLIF, emfilermin, AM424) to prevent chemotherapy-induced peripheral neuropathy. <i>Clinical Cancer Research</i>, 11, 1890-1898.

Argyriou, A.A., Chroni, E., Koutras, A., Ellul, J., Papapetropoulos, S., Katsoulas, G., et al. (2005). Vitamin E for prophylaxis against chemotherapy-induced neuropathy. <i>Neurology</i>, 64, 26-31.

Bove, L., Picardo, M., Maresca, V., Jaredolo, B., & Pace, A. (2001). A pilot study on the relation between cisplatin neuropathy and vitamin E. <i>Journal of Experimental and Clinical Cancer Research</i>, 20, 277-280.

Pace, A., Savarese, A., Picardo, M., Maresca, V., Pacetti, U., Del Monte, G., et al. (2003). Neuroprotective effect of vitamin E supplementation in patients treated with cisplatin chemotherapy. <i>Journal of Clinical Oncology</i>, 21, 927-931.

Wong, R., & Sagar, S. (2006). Acupuncture treatment for chemotherapyinduced peripheral neuropathy—A case series. <i>Acupuncture in Medicine</i>, 24, 87-91.

Jiang, H., Shi, K., Li, X., Zhou, W., & Cao, Y. (2006). Clinical study on the wristankle acupuncture treatment for 30 cases of diabetic peripheral neuritis. <i>Journal of Traditional Chinese Medicine</i>, 26, 8-12.

Shlay, J.D., Chaloner, K., Max, M.B., Flaws, B., Reichelderfer, P., Wentworth, D., et al. (1998). Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy. <i>JAMA</i>, 280, 1590-1595.

Abuaisha, B.B., Costanzi, J.B., & Boulton, A.J. (1998). Acupuncture for the treatment of chronic painful peripheral diabetic neuropathy: A long-term study. <i>Diabetes Research and Clinical Practice</i>, 39, 115-121.

Phillips, K.D., Skelton, W.D., & Hand, G.A. (2004). Effect of acupuncture administered in a group setting on pain and subjective peripheral neuropathy in persons with human immunodeficiency virus disease. <i>Journal of Alternative and Complementary Medicine</i>, 10, 449-455.

Forst, T., Nguyen, M., Forst, S., Disselhoff, B., Pohlmann, T., & Pfutzner, A. (2004). Impact of low frequency transcutaneous electrical nerve stimulation on symptomatic diabetic neuropathy using the new Salutaris device. <i>Diabetes, Nutrition and Metabolism</i>, 17, 163-168.

Lindeman, E., Leffers, P., Spaans, F., Drukker, J., Kerckhoffs, M., & Koke, A. (1995). Strength training in patients with myotonic dystrophy and hereditary motor and sensory neuropathy: A randomized clinical trial. <i>Archives of Physical Medicine and Rehabilitation</i>, 76, 612-620.

Richardson, J.K., Sandman, D., & Vela, S. (2001). A focused exercise regime improves clinical measures of balance in patients with peripheral neuropathy. <i>Archives of Physical Medicine and Rehabilitation</i>, 82, 205-209.

Balducci, S., Iacobellis, G., Parisi, L., Di Biase, N., Calandriello, E., Leonetti, F., et al. (2006). Exercise training can modify the natural history of diabetic peripheral neuropathy. <i>Journal of Diabetes and Its Complications</i>, 20, 216-223.

White, C.M., Pritchard, J., & Turner-Stokes, L. (2004). Exercise for people with peripheral neuropathy. <i>Cochrane Database of Systematic Reviews 2004, Issue 4.</i> Art. No.: CD003904. DOI: 10.1002/14651858.CD003904.pub2

Leonard, D.R., Farooqi, M.H., & Myers, S. (2004). Restoration of sensation, reduced pain, and improved balance in subjects with diabetic peripheral neuropathy. <i>Diabetes Care</i>, 27, 168-172.

Prendergast, J.J., Miranda, G., & Sanchez, M. (2004). Improvement of sensory impairment in patients with peripheral neuropathy. <i>Endocrine Practice</i>, 10, 24-30.

Arnall, D.A., Nelson, A.G., Lopez, L., Sanz, M., Iversen, L., Sanz, I., et al. (2006). The restorative effects of pulsed infrared light therapy on significant loss of peripheral protective sensation in patients with long-term type 1 and type 2 diabetes mellitus. <i>Acta Diabetologica</i>, 43, 26-33.

Cata, J.P., Cordella, J.V., Burton, A.W., Hassenbusch, S.J., Weng, H.R., & Dougherty, P.M. (2004). Spinal cord stimulation relieves chemotherapy-induced pain: A clinical case report. <i>Journal of Pain and Symptom Management</i>, 27, 72-78.

Reichstein, L., Labrenz, S., Ziegler, D., & Martin, S. (2005). Effective treatment of symptomatic diabetic polyneuropathy by high-frequency external muscle stimulation. <i>Diabetologia</i>, 48, 824-828.

Paice, J.A. (2007). Peripheral neuropathy: Experimental findings, clinical approaches. <i>Journal of Supportive Oncology</i>, 5, 61-63.

Armstrong, T., Almadrones, L., & Gilbert, M. (2005). Chemotherapy-induced peripheral neuropathy. <i>Oncology Nursing Forum</i>, 32, 305-311.

Marrs, J., & Newton, S. (2003). Updating your peripheral neuropathy "know how." <i>Clinical Journal of Oncology Nursing</i>, 7, 299-303.