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Article

PI3K Inhibitors and Adverse Events: Optimizing Patient Care for the Treatment of Advanced Breast Cancer

Sarah Donahue
Gretchen Santos Fulgencio
CJON 2020, 24(6), 673-680 DOI: 10.1188/20.CJON.673-680
Background: Excessive activation of the PI3K pathway has been associated with malignant transformation and resistance to treatment in various cancer types. Various PI3K inhibitors have been evaluated in phase 3 clinical trials; however, most have been associated with modest clinical improvement and...
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Article

Illness Uncertainty and Its Antecedents for Patients With Prostate Cancer and Their Partners

Ting Guan
Peiran Guo
Sheila Judge Santacroce
Ding-Geng Chen
Lixin Song
ONF 2020, 47(6), 721-731 DOI: 10.1188/20.ONF.721-731
Objectives: Guided by Mishel’s uncertainty in illness theory, patterns of change in uncertainty were explored over time for patients with prostate cancer and their partners. In addition, the relationships between uncertainty and its antecedents were examined, and the role effects (patient versus...
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Online Exclusive Article

Nurse-Led Telephonic Symptom Support for Patients Receiving Chemotherapy

Andra Davis
Janice F. Bell
Sarah C. Reed
Katherine K. Kim
Dawn Stacey
Jill G. Joseph
ONF 2020, 47(6), E199-E210 DOI: 10.1188/20.ONF.E199-E210
Problem Statement: The use of evidence-informed symptom guides has not been widely adopted in telephonic support. Design: This is a descriptive study of nurse-led support using evidence-based symptom guides during telephone outreach. Data Sources: Documentation quantified telephone encounters by...
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Essentials
NCPD Article

B-Cell Malignancies: The Use of Small Molecule Agents for Treatment and Management

Barbara B. Rogers
CJON 2020, 24(2), 199-204 DOI: 10.1188/20.CJON.199-204
Hematologic B-cell malignancies, which have varying behavior patterns, disease processes, and treatment responses, include non-Hodgkin lymphoma, leukemias, and myeloma. Although monoclonal antibodies and other agents have led to dramatic advances in the treatment of B-cell malignancies, the...
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Case Study

Managing Hot Flashes After Breast Cancer

Janet S. Carpenter
Beth Lambert
ONF 2000, 27(1), 23-25 DOI:
Mrs. C is a 49-year-old married woman who was diagnosed with breast cancer 16 months ago. She underwent a right modified radical mastectomy with immediate reconstruction followed by six cycles of adjuvant cyclophosphamide, methotrexate, and 5-fluorouracil.
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