Depression in Men With Prostate Cancer

Gerald Bennett

Terry A. Badger

ONF 2005, 32(3), 545-556. DOI: 10.1188/05.ONF.545-556

Purpose/Objectives: To summarize the current empirical knowledge base on depression in men with prostate cancer to inform psychosocial supportive care interventions for this population and chart directions for future research.

Data Sources: Reports in English of quantitative studies that included measures of depression or mood in samples of men with prostate cancer published from 1988-2004.

Data Synthesis: Nurse researchers are playing a key role in establishing the scientific knowledge base upon which a better understanding of the relative importance of depression in men with prostate cancer will emerge. This review indicates that (a) predictable risk factors exist for depression among men with prostate cancer, (b) different prostate cancer treatments do not tend to be associated with differential outcomes in depression or mood, and (c) overall, men with prostate cancer report fewer depressive symptoms than women with breast cancer.

Conclusions: The small body of research addressing depression in men with prostate cancer is methodologically inadequate to estimate the overall prevalence of depression among men with prostate cancer and determine the clinical significance of psychoeducational interventions targeting depression or mood in this population.

Implications for Nursing: Nurses can use current knowledge to identify men with prostate cancer who are most at risk for depression. Evidence supporting the benefit of psychoeducational interventions for depression in other cancer populations (e.g., women with breast cancer) may be applicable to men with prostate cancer.

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    American Cancer Society. (2005). Cancer facts and figures 2005. Atlanta, GA: Author.

    Balderson, N., & Towell, T. (2003). The prevalence and predictors of psychological distress in men with prostate cancer who are seeking support. British Journal of Health Psychology, 8, 125-134.

    Bandura, A. (1997). Self-efficacy: The exercise of control. New York: W.H. Freeman.

    Banthia, R., Malcarne, V.L., Varni, J.W., Ko, C.M., Sadler, G.R., & Green-bergs, H.L. (2003). The effects of dyadic strength and coping styles on psychological distress in couples faced with prostate cancer. Journal of Behavioral Medicine, 26, 31-52.

    Barsevick, A.M., Sweeney, C., Haney, E., & Chung, E. (2002). A systematic qualitative analysis of psychoeducational interventions for depression in patients with cancer. Oncology Nursing Forum, 29, 73-84.

    Beard, C.J., Propert, K.J., Rieker, P.P., Clark, J.A., Kaplan, I., Kantoff, P.W., et al. (1997). Complications after treatment with external-beam irradiation in early-stage prostate cancer patients: A prospective multiinstitutional outcomes study. Journal of Clinical Oncology, 15, 223-229.

    Bisson, J.I., Chubb, H.L., Bennett, S., Mason, M., Jones, D., & Kynaston, H. (2002). The prevalence and predictors of psychological distress in patients with early localized prostate cancer. BJU International, 90, 56-61.

    Blazer, D.G., Kessler, R.C., McGonagle, K.A., & Swartz, M.S. (1994). The prevalence and distribution of major depression in a national community sample: The National Comorbidity Survey. American Journal of Psychiatry, 151, 979-986.

    Carlson, L.E., Ottenbreit, N., St. Pierre, M., & Bultz, B.D. (2001). Partner understanding of the breast and prostate cancer experience. Cancer Nursing, 24, 231-239.

    Cassileth, B.R., Soloway, M.S., Vogelzang, N.J., Chou, J.M., Schellhammer, P.D., Seidmon, E.J., et al. (1992). Quality of life and psychosocial status in stage D prostate cancer. Quality of Life Research, 1, 323-329.

    Cliff, A.M., & MacDonagh, R.P. (2000). Psychosocial morbidity in prostate cancer II: A comparison of patients and partners. BJU International, 86, 834-839.

    Davison, B.J., & Degner, L.F. (1997). Empowerment of men newly diagnosed with prostate cancer. Cancer Nursing, 20, 187-196.

    Edwards, B.K., Howe, H.L., Ries, L.A., Thun, M.J., Rosenberg, H.M., Yancik, R., et al. (2002). Annual report to the nation on the status of cancer, 1973-1999, featuring implications of age and aging on U.S. cancer burden. Cancer, 94, 2766-2792.

    Ficarra, V., Righetti, R., D'Amico, A., Pilloni, S., Balzarro, M., Schiavone, D., et al. (2000). General state of health and psychological well-being in patients after surgery for urological malignant neoplasms. Urologia Internationalis, 65, 130-134.

    Fillion, L., Gelinas, C., Simard, S., Savard, J., & Gagnon, P. (2003). Validation evidence for the French Canadian adaptation of the Multidimensional Fatigue Inventory as a measure of cancer-related fatigue. Cancer Nursing, 26, 143-154.

    Heim, H.M., & Oei, T.P.S. (1993). Comparison of prostate cancer patients with and without pain. Pain, 53, 159-162.

    Helgesen, F., Andersson, S.O., Gustafsson, O., Varenhorst E., Goben, B., Carnock, S., et al. (2000). Follow-up of prostate cancer patients by on-demand contacts with specialist nurse: A randomized study. Scandinavian Journal of Urology and Nephrology, 34, 55-61.

    Howe, H.L., Wingo, P.A., Thun, M.J., Ries, L.A.G., Rosenberg, H.M., Feigal, E.G., et al. (2001). Annual report to the nation on the status of cancer (1973-1998), featuring cancers with recent increasing trends. Journal of the National Cancer Institute, 93, 824-842.

    Johnson, J.E. (1996). Coping with radiation therapy: Optimism and the effect of preparatory interventions. Research in Nursing and Health, 19, 3-12.

    Johnson, J.E., Fieler, V.K., Wlasowicz, G.S., Mitchell, M.L., & Jones, L.S. (1997). The effects of nursing care guided by self-regulation theory on coping with radiation therapy. Oncology Nursing Forum, 24, 1041-1050.

    Johnson, J.E., Lauver, D.R., & Nail, L.M. (1989). Process of coping with radiation therapy. Journal of Consulting and Clinical Psychology, 57, 358-364.

    Johnson, J.E., Nail, L.M., Lauver, D., King, K.B., & Keys, H. (1988). Reducing the negative impact of radiation therapy on functional status. Cancer, 61, 46-51.

    Kim, Y., Roscoe, J.A., & Morrow, G.R. (2002). The effects of information and negative affect on severity of side effects from radiation therapy for prostate cancer. Supportive Care in Cancer, 10, 416-421.

    Kornblith, A.B., Herr, H.W., Ofman, U.S., Scher, H.I., & Holland, J.C. (1994). Quality of life of patients with prostate cancer and their spouses: The value of a database in clinical care. Cancer, 73, 2791-2802.

    Kunkel, E.J., Bakker, J.R., Myers, R.E., Oyesanmi, O., & Gomella, L.G. (2000). Biopsychosocial aspects of prostate cancer. Psychosomatics, 41, 85-94.

    Lee, C., & Owens, G.R. (2002). The psychology of men's health. Buckingham, England: Open University Press.

    Lepore, S.J., Helgeson, V.S., Eton, D.T., & Schulz, R. (2003). Improving quality of life in men with prostate cancer: A randomized controlled trial of group education interventions. Health Psychology, 22, 443-452.

    Lintz, K., Moynihan, C., Steginga, S., Norman, A., Eeles, R., Huddart, R., et al. (2003). Prostate cancer patients' support and psychological care needs: Survey from a non-surgical oncology clinic. Psycho-Oncology, 12, 769-783.

    Lynch, J., & Kilmartin, C.T. (1999). The pain behind the mask: Overcoming masculine depression. Binghamton, NY: Haworth Press.

    McDaniel, J.S., Musselman, D.L., Porter, M.R., Reed, D.A., & Nemeroff, C.B. (1995). Depression in patients with cancer. Diagnosis, biology, and treatment. Archives of General Psychiatry, 52, 89-99.

    Meyer, T.J., & Mark, M.M. (1995). Effects of psychosocial interventions with adult cancer patients: A meta-analysis of randomized experiments. Health Psychology, 14, 101-108.

    Moller-Leimkuhler, A.M. (2002). Barriers to help-seeking by men: A review of sociocultural and clinical literature with particular reference to depression. Journal of Affective Disorders, 71(1-3), 1-9.

    Monga, U., Kerrigan, A.J., Thornby, J., & Monga, T.N. (1999). Prospective study of fatigue in localized prostate cancer patients undergoing radio-therapy. Radiation Oncology Investigations, 7, 178-185.

    Nordin, K., Berglund, G., Glimelius, B., & Sjoden, P.O. (2001). Predicting anxiety and depression among cancer patients: A clinical model. European Journal of Cancer, 37, 376-384.

    Parker, P.A., Baile, W.F., de Moor, C., & Cohen, L. (2003). Psychosocial and demographic predictors of quality of life in a large sample of cancer patients. Psycho-Oncology, 12, 183-193.

    Parmar, H., Phillips, R.H., Lightman, S.L., & Edwards, L. (1988). How would you like to have an orchidectomy for advanced prostatic cancer? American Journal of Clinical Oncology, 11(Suppl. 2), S160-S168.

    Penedo, F.J., Dahn, J.R., Gonzalez, J.S., Molton, I., Carver, C.S., Antoni, M.H., et al. (2003). Perceived stress management skill mediates the relationship between optimism and positive mood following radical prostatectomy. Health Psychology, 22, 220-222.

    Perez, M.A., Skinner, E.C., & Meyerowitz, B.E. (2002). Sexuality and intimacy following radical prostatectomy: Patient and partner perspectives, Health Psychology, 21, 288-293.

    Pirl, W.F., & Mello, J. (2002). Psychological complications of prostate cancer. Oncology, 16, 1448-1453.

    Pirl, W.F., Siegel, G.I., Goode, M.J., & Smith, M.R. (2002). Depression in men receiving androgen deprivation therapy for prostate cancer: A pilot study. Psycho-Oncology, 11, 518-523.

    Ritterband, L.M., & Spielberger, C.D. (2001). Depression in a cancer population. Journal of Clinical Psychology in Medical Settings, 8, 85-93.

    Rondorf-Klym, L.M., & Colling, J. (2003). Quality of life after radical prostatectomy [Online exclusive]. Oncology Nursing Forum, 30, E24-E32. Retrieved March 4, 2005, from

    Rosenberg, H.J., Rosenberg, S.D., Ernstoff, M.S., Wolford, G.L., Amdur, R.J., Elshamy, M.R., et al. (2002). Expressive disclosure and health outcomes in a prostate cancer population. International Journal of Psychiatry in Medicine, 32(1), 37-53.

    Roth, A.J., Kornblith, A.B., Batel-Copel, L., Peabody, E., Scher, H.I., & Holland, J.C. (1998). Rapid screening for psychologic distress in men with prostate carcinoma: A pilot study. Cancer, 82, 1904-1908.

    Salminen, E., Portin, R., Korpela, J., Backman, H., Parvinen, L.M., Helenius, H., et al. (2003). Androgen deprivation and cognition in prostate cancer. British Journal of Cancer, 89, 971-976.

    Salokangas, R.K., Vaahtera, K., Pacriev, S., Sohlman, B., & Lehtinen, V. (2002). Gender differences in depressive symptoms: An artefact caused by measurement instruments? Journal of Affective Disorders, 68, 215-220.

    Schag, C.A.C., Ganz, P.A., Wing, D.S., Sim, M.S., & Lee, J.J. (1994). Quality of life in adult survivors of lung, colon, and prostate cancer. Quality of Life Research, 3, 127-141.

    Stanford, J.L., Stephenson, R.A., Coyle, L.M., Cerhan, J., Correa, R., Eley, J.W., et al. (1999). Prostate cancer trends 1973-1995 [National Institutes of Health Publication Number 99-4543). Bethesda, MD: Surveillance, Epidemiology, and End Results Program, National Cancer Institute.

    Steineck, G., Helgesen, F., Adolfsson, J., Dickman, P.W., Johansson, J.E., Norlen, B.J., et al. (2002). Quality of life after radical prostatectomy or watchful waiting. New England Journal of Medicine, 347, 790-796.

    Stone, P., Hardy, J., Huddart, R., A'Hern, R., & Richards, M. (2000). Fatigue in patients with prostate cancer receiving hormone therapy. European Journal of Cancer, 36, 1134-1141.

    Strouse, T. (1999). Identifying and treating depression in women with cancer: A primary care approach. Medscape General Medicine, 1(2). Retrieved May 7, 2004, from

    Taxel, P., Stevens, M.C., Trahiotis, M., Zimmerman, J., & Kaplan, R.F. (2004). The effect of short-term estradiol therapy on cognitive function in older men receiving hormonal suppression therapy for prostate cancer. Journal of the American Geriatrics Society, 52, 269-273.

    Ullrich, P.M., Carson, M.R., Lutgendorf, S.K., & Williams, R.D. (2003). Cancer fear and mood disturbance after radical prostatectomy: Consequences of biochemical evidence of recurrence. Journal of Urology, 169, 1449-1452.

    U.S. Cancer Statistics Working Group. (2002). United States cancer statistics: 1999 incidence. Atlanta, GA: Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute.

    Visser, A., van Andel, G., Willems, P., Voogt, E., Dijkstra, A., Rovers, P., et al. (2003). Changes in health-related quality of life of men with prostate cancer three months after diagnosis: The role of psychosocial factors and comparisment with benign prostate hyperplasia patients. Patient Education and Counseling, 49, 225-232.

    Weber, B.A., Roberts, B.L., Resnick, M., Deimling, G., Zauszniewski, J.A., Musil, C., et al. (2004). The effect of dyadic intervention on self-efficacy, social support, and depression for men with prostate cancer. Psycho-Oncology, 13, 47-60.

    Yaffe, K., Sawaya, G., Lieberburg, I., & Grady, D. (1998). Estrogen therapy in postmenopausal women: Effects on cognitive function and dementia. JAMA, 279, 688-695.

    Zabora, J., Brintzenhofeszoc, K., Curbow, B., Hooker, C., & Piantadosi, S. (2001). The prevalence of psychological distress by cancer site. Psycho-Oncology, 10, 19-28.