Thompson, E.A., & Reilly, D. (2003). The homeopathic approach to the treatment of symptoms of oestrogen withdrawal in breast cancer patients: A prospective observational study. Homeopathy, 92, 131–134.

DOI Link

Study Purpose

The study explored a homeopathic approach to treatment of estrogen-withdrawal symptoms in women with breast cancer.

Intervention Characteristics/Basic Study Process

Active intervention was a homeopathic approach, which included a 60-minute consultation and the prescription of an individualized homeopathic remedy. A total of 25 remedies were used for the first prescription. Pulsatilla, Sepia, and sulfur were each used on more than three occasions for the first prescription.

Sample Characteristics

The study enrolled: 45 participants who ranged in age from 34 to 71 years; just over half were aged 50–59 years.

  • Inclusion criteria:
    • 45 consecutive patients seen at the outpatient clinic at Glasgow Homeopathic Hospital with breast cancer and estrogen withdrawal symptoms 
    • 32 participants were taking tamoxifen
    • 21 had undergone adjuvant chemotherapy
    • 20 were taking medications such as antidepressants and clonidine
    • 3 had metastatic disease at study entry 
  • Exclusion criteria: None

Study Design

This was a prospective observational study.

Measurement Instruments/Methods

The study used a numerical self-rating scale, where 0 = no problem, and 10 = tremendous problem, to identify patient symptoms. Hot flashes were rated as the most common symptom (n = 38).

Results

A data table showed significant improvement in hot flashes between baseline and last visit (p < 0.001).

Limitations

The study used a small, convenience sample of consecutive patients, some of who were taking antidepressants (not specified) and clonidine, which may both be used to manage hot flashes. The length of study and schedule of follow up visits were not apparent. Assessment of hot flash frequency and severity was not the primary outcome measure of the study, only one of several symptoms assessed. Primary endpoint was the “effect on daily living” scores. Homeopathy regimens were not defined, which could pose a problem for study replication. Exact reduction in hot flashes was difficult to determine.