Survivorship care is complex. This supplement captures an updated foundation about clinical care of cancer survivors in two main sections. The first is a deep-dive comprehensive review of cancer- and treatment-related long-term symptoms or issues related to survivorship care. Compiled by APNs, the reviews about chest pain, sexual dysfunction, dyspnea (shortness of breath), germline (hereditary) predisposition to cancer, and bone loss/osteoporosis in cancer survivors were selected because the standards of care and guidelines about these topics are still evolving. In the second section, a panel of APNs comment on four case studies of survivors, representing four common cancer diagnoses (i.e., breast, colon, and prostate cancers and a hematologic malignancy) in an effort to create a fresh conversation about approaches and clinical strategies to care for cancer survivors.